Ueda S, Sano Y, Kawata M
Department of Anatomy, Kyoto Prefectural University of Medicine, Japan.
Brain Res. 1991 Aug 16;556(2):329-32. doi: 10.1016/0006-8993(91)90325-p.
The parietal cortex and dorsal hippocampus of adult rats were unilaterally ablated. One and 3 months after this operation, changes in serotonergic fiber distribution in the forebrain were studied immunohistochemically. At 1 month, increased numbers of serotonergic fibers were seen in the cingulate cortex and the medial and lateral septal nuclei of the lesioned side. This increase continued to 3 months in the ipsilateral cingulate cortex. In the present study, two different processes of serotonergic fiber collateral sprouting were noted. Plastic changes in serotonergic fibers in the ipsilateral septal nuclei and cingulate cortex may be attributable to the collateral sprouting underlying reactive synaptogenesis and the pruning effect, respectively.
成年大鼠的顶叶皮质和背侧海马被单侧切除。在该手术后1个月和3个月，采用免疫组织化学方法研究前脑5-羟色胺能纤维分布的变化。在1个月时，在损伤侧的扣带回皮质以及内侧和外侧隔核中可见5-羟色胺能纤维数量增加。这种增加在同侧扣带回皮质持续到3个月。在本研究中，观察到5-羟色胺能纤维侧支发芽的两个不同过程。同侧隔核和扣带回皮质中5-羟色胺能纤维的可塑性变化可能分别归因于反应性突触发生和修剪效应潜在的侧支发芽。
