Kinghorn A Douglas, Chin Young-Won, Swanson Steven M
Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Curr Opin Drug Discov Devel. 2009 Mar;12(2):189-96.
Since the early 1960s, small organic molecules derived naturally from microbes and plants have provided a number of useful cancer chemotherapeutic drugs. The search for naturally occurring lead compounds of this type has continued in recent years, with the constituents of marine fauna and flora as well as those of terrestrial microorganisms and plants being investigated for their anticancer activities. In the present short review, selected novel compounds that have been obtained from organisms of diverse biological origin, or their derivatives, are discussed in terms of their potential use as cancer chemotherapeutic agents. Such promising lead compounds tend to generate considerable interest among scientists such as synthetic organic chemists and biologists. Consequently, the supply of a given precious natural product sample may be enhanced, and it may be possible to determine a preliminary notion of structure-activity relationships and of its potential mechanism of action.
自20世纪60年代初以来，天然源自微生物和植物的小分子有机化合物已提供了多种有用的癌症化疗药物。近年来，人们一直在寻找这类天然存在的先导化合物，对海洋动植物以及陆地微生物和植物的成分进行抗癌活性研究。在本简短综述中，将从其作为癌症化疗药物的潜在用途方面，讨论从不同生物来源的生物体中获得的选定新型化合物或其衍生物。这类有前景的先导化合物往往会引起合成有机化学家、生物学家等科学家的极大兴趣。因此，可能会增加给定珍贵天然产物样品的供应量，并且有可能确定结构-活性关系及其潜在作用机制的初步概念。
