Takizawa Toshiya, Watanabe Kazuhiro, Narita Koichi, Oguchi Takamasa, Abe Hideki, Katoh Tadashi
Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Chem Commun (Camb). 2008 Apr 14(14):1677-9. doi: 10.1039/b718310k. Epub 2008 Feb 5.
The first total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, was achieved in a convergent manner; the synthesis established stereochemistry at the C5'' position.
强效组蛋白去乙酰化酶抑制剂螺旋抑素B的首次全合成以汇聚式方法完成；该合成确定了C5'' 位置的立体化学。
