Cancela L M, Rossi S, Molina V A
Departamento de Farmacología, Facultad de Ciencias Químicas Universidad Nacional de Córdoba, Argentina.
Brain Res Bull. 1991 May;26(5):671-5. doi: 10.1016/0361-9230(91)90159-h.
The present research was conducted to evaluate the influence of different stress schedules on behaviors displayed during both phases of the forced swim test (FST). In addition, the involvement of an opiate mechanism in the behavioral consequences of chronic restraint was investigated. Exposure to a single, but not to chronic, restraint event induced an increase in the immobility score obtained during the 10-min initial swimming exposure (initial test) of the FST. Animals submitted to a previous regime of repeated restraint showed a significant increase in immobility during the 5-min second swimming exposure (retest period) of this behavioral task. However, naloxone (NAL) administered before each of the seven restraint events, blocked the higher immobility observed in chronically stressed rats during the retest period suggesting the involvement of an opiate mechanism. Results concerning the effect of chronic stress on the behavior displayed during the FST were discussed with reference to previous reports which have proposed that immobility performed during the retest period of the FST represents an efficient adaptive response in this inescapable aversive experience.
本研究旨在评估不同应激方案对强迫游泳试验（FST）两个阶段所表现出的行为的影响。此外，还研究了阿片类机制在慢性束缚行为后果中的作用。单次而非慢性束缚事件会导致FST初始10分钟游泳暴露（初始试验）期间的不动时间得分增加。经历过重复束缚先前方案的动物在该行为任务的5分钟第二次游泳暴露（重新测试期）期间的不动时间显著增加。然而，在七次束缚事件中的每次之前给予纳洛酮（NAL），可阻断慢性应激大鼠在重新测试期观察到的较高不动时间，提示阿片类机制的参与。关于慢性应激对FST期间所表现行为的影响的结果，参考了先前的报告进行了讨论，这些报告提出FST重新测试期的不动代表了这种不可逃避的厌恶经历中的一种有效适应性反应。
