对水迷宫和被动回避行为表现中，毒蝇蕈氨酸和鹅膏蕈氨酸损毁基底核大细胞部的比较。

Comparison of quisqualic and ibotenic acid nucleus basalis magnocellularis lesions on water-maze and passive avoidance performance.

作者信息

Riekkinen M, Riekkinen P, Riekkinen P

机构信息

Department of Neurology, University of Kuopio, Finland.

出版信息

Brain Res Bull. 1991 Jul;27(1):119-23. doi: 10.1016/0361-9230(91)90292-r.

DOI:10.1016/0361-9230(91)90292-r

PMID:1933423

Abstract

The present study compares water-maze (WM) (reference and working memory) and passive avoidance (PA) (acquisition and retention) deficits induced by ibotenic (ibo) and quisqualic (quis) acid nucleus basalis magnocellularis (NBM) lesions. Ibo lesions produced a large subcortical cell loss and a decrease in frontal cortex (FR) choline acetyltransferase (ChAT) activity. Ibo lesions impaired WM acquisition and PA acquisition and retention performance. Quis NBM lesions were restricted to the ventromedial pallidum, but ChAT activity was decreased in FR. Quis NBM lesions impaired PA acquisition and retention, but had no effect on the reference or working memory WM performance.

摘要

本研究比较了鹅膏蕈氨酸（ibo）和喹啉酸（quis）损毁基底大细胞核（NBM）所诱导的水迷宫（WM）（参考记忆和工作记忆）及被动回避（PA）（习得和保持）缺陷。Ibo损毁导致大量皮质下细胞丢失以及额叶皮质（FR）胆碱乙酰转移酶（ChAT）活性降低。Ibo损毁损害了WM习得以及PA习得和保持表现。Quis NBM损毁局限于腹内侧苍白球，但FR中的ChAT活性降低。Quis NBM损毁损害了PA习得和保持，但对参考记忆或工作记忆的WM表现没有影响。