Riekkinen M, Riekkinen P, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Brain Res Bull. 1991 Jul;27(1):119-23. doi: 10.1016/0361-9230(91)90292-r.
The present study compares water-maze (WM) (reference and working memory) and passive avoidance (PA) (acquisition and retention) deficits induced by ibotenic (ibo) and quisqualic (quis) acid nucleus basalis magnocellularis (NBM) lesions. Ibo lesions produced a large subcortical cell loss and a decrease in frontal cortex (FR) choline acetyltransferase (ChAT) activity. Ibo lesions impaired WM acquisition and PA acquisition and retention performance. Quis NBM lesions were restricted to the ventromedial pallidum, but ChAT activity was decreased in FR. Quis NBM lesions impaired PA acquisition and retention, but had no effect on the reference or working memory WM performance.
本研究比较了鹅膏蕈氨酸（ibo）和喹啉酸（quis）损毁基底大细胞核（NBM）所诱导的水迷宫（WM）（参考记忆和工作记忆）及被动回避（PA）（习得和保持）缺陷。Ibo损毁导致大量皮质下细胞丢失以及额叶皮质（FR）胆碱乙酰转移酶（ChAT）活性降低。Ibo损毁损害了WM习得以及PA习得和保持表现。Quis NBM损毁局限于腹内侧苍白球，但FR中的ChAT活性降低。Quis NBM损毁损害了PA习得和保持，但对参考记忆或工作记忆的WM表现没有影响。
