Vakhrushev Ia M, Potapova L O, Muravtseva O V
Ter Arkh. 2009;81(2):27-30.
To specify dysfunction of the stomach and duodenum in gastroesophageal reflux disease (GRD) to offer more effective pathogenetic pharmacotherapy of GRD.
Fibroesophagogastroduodenoscopy with further assessment of esophageal mucosa condition by Savary-Miller, intragastric pH-metry, dynamic gastroscintigraphy and electrogastrography were made in 150 GRD patients.
GRD patients were found to have significant disturbances of a motor-evacuatory function of the gastroduodenal complex. Addition of domperidon and mebeverin to routine combined treatment of GRD raises clinical efficacy of GRD treatment and promotes recovery of gastric and duodenal function though therapeutic efficacy of the above drugs depended on concomitant pathology.
Domperidon and mebeverin addition to combined treatment of GRD makes this treatment more effective.
明确胃食管反流病（GRD）中胃和十二指肠的功能障碍，为GRD提供更有效的病因性药物治疗。
对150例GRD患者进行了纤维食管胃十二指肠镜检查，并通过Savary-Miller法进一步评估食管黏膜状况、胃内pH测定、动态胃闪烁显像和胃电图检查。
发现GRD患者胃十二指肠复合体的运动排空功能存在明显障碍。在GRD的常规联合治疗中加用多潘立酮和美贝维林可提高GRD治疗的临床疗效，并促进胃和十二指肠功能的恢复，不过上述药物的治疗效果取决于伴随的病理情况。
在GRD的联合治疗中加用多潘立酮和美贝维林可使治疗更有效。
