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[苯乙胺对大鼠脑半球间传递的影响]

[Effect of phenibut on interhemispheric transmission in the rat brain].

作者信息

Borodkina L E, Molodavkin G M, Tiurenkov I N

出版信息

Eksp Klin Farmakol. 2009 Jan-Feb;72(1):57-9.

PMID:19334513
Abstract

Effects of the nootropic drug phenibut on the transcallosal potential amplitude in the sensomotor brain cortex have been studied in rats. It is established that a single administration of phenibut in a dose of 25 mg/kg (i.p.) increases the transcallosal response amplitude, thus improving the interhemispheric transmission. This effect, being an objective evidence of the nootrope activity, confirms the drug status and corroborates the positive action of phenibut on the learning and memory processes.

摘要

已在大鼠中研究了益智药苯乙胺对感觉运动脑皮质胼胝体电位振幅的影响。已确定,以25mg/kg(腹腔注射)的剂量单次给予苯乙胺可增加胼胝体反应振幅,从而改善半球间传递。这种效应作为益智活性的客观证据,证实了该药物的状态,并确证了苯乙胺对学习和记忆过程的积极作用。

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