Li Liangcheng, Zhang Yongshun, Li Zhonghong
Staff Room of Medical Image, Bethune Military Medical College, Shijiazhuang 050081, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Feb;26(1):184-6.
The recent fast development in biotechnology has resulted in a large number of therapeutic biologicals coming in the foreground for clinical application. Transdermal drug delivery (TDD) is designed for patching the drug on the skin, and then the drug molecules permeate through the skin into the subcutaneous capillary vessels. However,very few drugs can be administered transdermally at the therapeutic levels to pass through the barrier of stratum corneum. Several physical and chemical methods are applied to improve the permeability of skin. Research result shows that the low-frequency ultrasonic technique can extraordinarily increase the rate of permeation. As a result, it is becoming one of the potential methods that serve as the substitutes for traditional methods. In this paper is presented a type of equipment based on MSP430. The principle of design, the structure of hardware, and the applied function in this area are described.
生物技术领域近年来的快速发展使得大量治疗性生物制品走向临床应用前台。经皮给药（TDD）旨在将药物贴敷于皮肤上，然后药物分子透过皮肤进入皮下毛细血管。然而，能以治疗剂量经皮给药并穿透角质层屏障的药物极少。人们应用了多种物理和化学方法来提高皮肤的通透性。研究结果表明，低频超声技术可显著提高渗透速率。因此，它正成为有望替代传统方法的潜在方法之一。本文介绍了一种基于MSP430的设备。阐述了其设计原理、硬件结构以及在该领域的应用功能。
