Hupfeld Stefan, Gravem Hilde
Institutt for farmasiDet medisinske fakultetUniversitetet i Tromsø9037 Tromsø.
Tidsskr Nor Laegeforen. 2009 Mar 12;129(6):532-3. doi: 10.4045/tidsskr.09.33349.
Transdermal therapeutic systems, or transdermal patches, facilitate controlled release of active ingredients through the skin and into the systemic circulation. Drugs administered through such systems escape first pass metabolism and steady state is maintained similar to a continuous intravenous infusion for up to several days. Few pharmacologically active substances can currently be administered through transdermal patches and production is technically demanding. Research is ongoing to improve the systems and expand the indications. This article gives a brief overview over principles behind various transdermal patch types, as well as the advantages and disadvantages of transdermal therapeutic systems.
透皮治疗系统，即透皮贴剂，有助于活性成分通过皮肤并进入体循环实现控释。通过此类系统给药的药物可避免首过代谢，并且能维持稳态，类似于持续静脉输注，长达数天。目前，仅有少数药理活性物质可通过透皮贴剂给药，且生产技术要求较高。正在进行相关研究以改进该系统并扩大其适应症。本文简要概述了各种类型透皮贴剂背后的原理，以及透皮治疗系统的优缺点。
