[诱导多能干细胞]

[Induced pluripotent stem cells].

作者信息

Shevchenko A I, Medvedev S P, Mazurok N A, Zakiian S M

出版信息

Genetika. 2009 Feb;45(2):160-8.

PMID:19334609

Abstract

Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC). To date, iPS have been obtained from various differentiated cells of mice and humans. Along with ESC, iPS are highly promising for research and medicine.

摘要

诱导多能干细胞（iPS）是通过用表达Oct4、Sox2、c-Myc、Klf4、Nanog和Lin28基因的病毒载体转导来重编程体细胞而产生的，这些基因对于多能状态的建立和维持至关重要。在特性上，iPS几乎与胚胎干细胞（ESC）完全相似。迄今为止，已从小鼠和人类的各种分化细胞中获得了iPS。与ESC一样，iPS在研究和医学方面极具前景。