颈动脉压力感受器刺激作为高血压及其他心血管疾病的治疗靶点。
Carotid baroreceptor stimulation as a therapeutic target in hypertension and other cardiovascular conditions.
作者信息
Doumas Michael, Guo Daqing, Papademetriou Vasilios
机构信息
Hypertension and Cardiovascular Research Clinic, Veterans Affairs and Georgetown University Medical Centers, VAMC 151-E, NW, Washington, DC 20422, USA.
出版信息
Expert Opin Ther Targets. 2009 Apr;13(4):413-25. doi: 10.1517/14728220902780185.
BACKGROUND
The role of the carotid baroreflex in blood pressure regulation has been known for a long time but its effects were thought to be short lived. Recent data indicate that stimulation of carotid baroreceptors may lower blood pressure not only for short periods of time, but also in the long run.
OBJECTIVE/METHODS: Recent advances in technology permitted the development of a new device (Rheos) that addresses problems with older devices. Several questions remain to be addressed before Rheos can be used widely, and several potential clinical applications remain to be clarified. This review examines these issues and comprehensively describes this therapeutic approach.
RESULTS/CONCLUSIONS: The carotid baroreceptor reflex is probably not completely in control of blood pressure. Baroreflexes are one of many control systems acting in concert.
背景
颈动脉压力反射在血压调节中的作用早已为人所知，但其作用被认为是短暂的。最近的数据表明，刺激颈动脉压力感受器不仅可在短时间内降低血压，而且从长远来看也能降低血压。
目的/方法：技术的最新进展使得一种新设备（Rheos）得以开发，该设备解决了旧设备存在的问题。在Rheos能够广泛应用之前，仍有几个问题有待解决，一些潜在的临床应用也有待阐明。本综述探讨了这些问题，并全面描述了这种治疗方法。
结果/结论：颈动脉压力感受器反射可能并未完全控制血压。压力反射是协同作用的众多控制系统之一。
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