McAllister Bradley S, Haghighat Kamran, Gonshor Aron
Private practice, Portland, OR, USA.
J Periodontol. 2009 Apr;80(4):679-86. doi: 10.1902/jop.2009.080345.
Predictability has been demonstrated for the long-term success of dental implants placed simultaneously with or after a sinus-augmentation procedure. However, the time required to obtain optimal bone formation can be from 6 to 9 months or longer with grafting materials other than autogenous bone. For this reason, there is interest in a surgical technique that does not require the harvest of autogenous bone but still results in sufficient bone formation within a relatively short time frame.
The purpose of this case series was to evaluate the bone formation following sinus-augmentation procedures using an allograft cellular bone matrix containing native mesenchymal stem cells. Biopsy and histologic evaluation were performed after approximately 4 months of healing.
Histomorphometric analysis revealed an average vital bone content of 33% (range, 22% to 40%) and an average residual graft content of 6% (range, 3% to 7%) for the five cases reported that had an average healing period of 4.1 months (range, 3 to 4.75 months).
The high percentage of vital bone content, after a relatively short healing phase, may encourage a more rapid initiation of implant placement or restoration when a cellular grafting approach is considered.
已证实，在进行上颌窦提升手术的同时或之后植入牙种植体，长期成功率具有可预测性。然而，使用自体骨以外的移植材料时，获得最佳骨形成所需的时间可能为6至9个月或更长。因此，人们对一种不需要采集自体骨但仍能在相对较短时间内实现充分骨形成的手术技术感兴趣。
本病例系列的目的是评估使用含有天然间充质干细胞的同种异体骨细胞基质进行上颌窦提升手术后的骨形成情况。在愈合约4个月后进行活检和组织学评估。
组织形态计量学分析显示，报告的5例病例平均愈合期为4.1个月（范围3至4.75个月），平均活性骨含量为33%（范围22%至40%），平均残余移植物含量为6%（范围3%至7%）。
在相对较短的愈合期后，活性骨含量的高百分比可能会促使在考虑采用细胞移植方法时更快地开始种植体植入或修复。
