Koethe Dagmar, Giuffrida Andrea, Schreiber Daniela, Hellmich Martin, Schultze-Lutter Frauke, Ruhrmann Stefan, Klosterkötter Joachim, Piomelli Daniele, Leweke F Markus
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany.
Br J Psychiatry. 2009 Apr;194(4):371-2. doi: 10.1192/bjp.bp.108.053843.
Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=81) using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.
花生四烯乙醇胺是一种与大麻素受体结合的生物活性脂质。已有研究表明花生四烯乙醇胺在精神分裂症中具有稳态调节作用。我们研究了其在精神病初始前驱状态中的作用。我们使用高效液相色谱/质谱法测量了处于初始前驱状态的患者（n = 27）以及健康志愿者（n = 81）脑脊液和血清中花生四烯乙醇胺及其结构类似物油酰乙醇胺的水平。患者脑脊液中花生四烯乙醇胺水平显著升高。水平较低的患者更早转变为精神病的风险更高。在初始前驱病程中这种内源性大麻素上调可能表明内源性大麻素系统在早期精神分裂症中具有保护作用。
