Nalbantoglu J
Department of Medicine, McGill Center for Studies in Aging, McGill University, Montreal, Quebec, Canada.
Can J Neurol Sci. 1991 Aug;18(3 Suppl):424-7. doi: 10.1017/s0317167100032595.
Beta-amyloid protein, a 42-43 amino acid polypeptide, accumulates abnormally in senile plaques and the cerebral vasculature in Alzheimer's disease. This polypeptide is derived from a membrane-associated precursor which has several isoforms expressed in many tissues. The precursor protein is processed constitutively within the beta-amyloid domain, leading to the release of the large N-terminal portion into the extracellular medium. beta-amyloid protein may be toxic to certain neuronal cell types and its early deposition may be an important event in the pathogenesis of Alzheimer's disease.
β-淀粉样蛋白是一种由42 - 43个氨基酸组成的多肽，在阿尔茨海默病的老年斑和脑血管中异常积聚。这种多肽源自一种膜相关前体，该前体有多种异构体，在许多组织中表达。前体蛋白在β-淀粉样蛋白结构域内持续进行加工处理，导致其大的N端部分释放到细胞外介质中。β-淀粉样蛋白可能对某些神经元细胞类型有毒性，其早期沉积可能是阿尔茨海默病发病机制中的一个重要事件。
