腺苷对肾小动脉张力的调节：2型受体的新作用。
Regulation of renal arteriolar tone by adenosine: novel role for type 2 receptors.
作者信息
Bell Tracy D, Welch William J
出版信息
Kidney Int. 2009 Apr;75(8):769-71. doi: 10.1038/ki.2009.18.
Abstract
Tubuloglomerular feedback regulation of glomerular filtration rate (GFR) is mediated by adenosine, which acts on type 1 receptors in the afferent arteriole to increase resistance. However, new findings in isolated mouse tissue suggest that adenosine also dilates the efferent arteriole, which would reinforce the ability of adenosine to reduce GFR. This new information extends the concept that adenosine acts as a paracrine agent on both afferent and efferent arterioles.
摘要
肾小球滤过率（GFR）的球管反馈调节由腺苷介导，腺苷作用于入球小动脉的1型受体以增加阻力。然而，在分离的小鼠组织中的新发现表明，腺苷也会扩张出球小动脉，这将增强腺苷降低GFR的能力。这一新信息扩展了腺苷作为旁分泌因子作用于入球小动脉和出球小动脉的概念。
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本文引用的文献
1
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Kidney Int. 2009 Apr;75(8):793-9. doi: 10.1038/ki.2008.684. Epub 2009 Jan 21.
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Adenosine A2 receptor activation attenuates afferent arteriolar autoregulation during adenosine receptor saturation in rats.在大鼠腺苷受体饱和期间，腺苷A2受体激活减弱传入小动脉的自身调节。
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Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine.肾小球滤过的肾小管-肾小球反馈调节介质：ATP和腺苷。
Acta Physiol (Oxf). 2007 Jan;189(1):3-14. doi: 10.1111/j.1748-1716.2006.01610.x.
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Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice.腺苷A1受体缺陷小鼠的球管反馈被消除且血浆肾素增加。
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Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9983-8. doi: 10.1073/pnas.171317998.
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Am J Physiol Renal Physiol. 2001 Mar;280(3):F406-14. doi: 10.1152/ajprenal.2001.280.3.F406.
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Efferent arteriole tubuloglomerular feedback in the renal nephron.肾单位中出球小动脉的管球反馈
Kidney Int. 2001 Jan;59(1):222-9. doi: 10.1046/j.1523-1755.2001.00482.x.
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