Ecker Karin, Hengst Ludger
Nat Cell Biol. 2009 Apr;11(4):377-9. doi: 10.1038/ncb0409-377.
To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.
为了控制细胞增殖，信号转导需要调节细胞周期机制。最近的研究结果表明，Akt（一种协调多种信号通路的主要激酶）可使Skp2磷酸化，Skp2是SCF-Skp2泛素连接酶的一个亚基，该连接酶靶向关键的细胞周期调节因子。Akt1依赖性磷酸化通过多种机制激活SCF-Skp2。
