Molden Espen, Spigset Olav
Farmasøytisk institutt Universitetet i Oslo Postboks 1068 Blindern 0316 Oslo.
Tidsskr Nor Laegeforen. 2009 Mar 26;129(7):632-3. doi: 10.4045/tidsskr.08.0122.
Tobacco smoking increases the turnover of many drugs due to induction of drug-metabolizing enzymes. Smokers therefore require higher doses of agents such as clozapine, olanzapine and theophylline than non- smokers. Enzyme induction declines after smoking cessation and without concomitant dose reduction there is an increased risk of adverse effects.
吸烟会诱导药物代谢酶，从而增加许多药物的代谢率。因此，与不吸烟者相比，吸烟者需要更高剂量的药物，如氯氮平、奥氮平和茶碱。戒烟后酶诱导作用会减弱，如果不相应降低剂量，出现不良反应的风险就会增加。
