George Anil, Movahed Assad
Professor of Medicine and Radiology, Associate Division Chief, Director of Nuclear Cardiology, Cardiovascular Science Department, Director of Cardiovascular Imaging Center, The Brody School of Medicine, Pitt County Memorial Hospital, 600 Moye Boulevard, Greenville, NC 27834, USA.
Open Cardiovasc Med J. 2008;2:87-92. doi: 10.2174/1874192400802010087. Epub 2008 Sep 18.
Most incident coronary disease occurs in previously asymptomatic individuals who were considered to be at a lower risk by traditional screening methods. There is a definite advantage if these individuals could be reclassified into a higher risk category, thereby impacting disease outcomes favorably. Coronary artery calcium scores have been recognized as an independent marker for adverse prognosis in coronary disease. Multiple population based studies have acknowledged the shortcomings of risk prediction models such as the Framingham risk score or the Procam score. The science behind coronary calcium is discussed briefly followed by a review of current thinking on calcium scores. An attempt has been made to summarize the appropriate indications and use of calcium scores.
大多数新发冠心病发生在既往无症状的个体中，这些个体通过传统筛查方法被认为风险较低。如果能将这些个体重新分类为高风险类别，从而对疾病转归产生有利影响，那将具有明确的优势。冠状动脉钙化积分已被公认为冠心病不良预后的独立标志物。多项基于人群的研究已认识到风险预测模型（如弗雷明汉风险评分或普洛卡姆评分）的不足之处。本文将简要讨论冠状动脉钙化背后的科学原理，随后回顾有关钙化积分的当前观点。已尝试总结钙化积分的适当适应证及应用。
