Wong David M, Vo Dai Tan, Alcott Cody J, Stewart Allison J, Peterson Anna D, Sponseller Brett A, Hsu Walter H
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.
Can J Vet Res. 2009 Jan;73(1):65-72.
The purpose of this study was to investigate total baseline plasma cortisol and adrenocorticotropic hormone (ACTH) concentrations, and ACTH-stimulated cortisol concentrations in foals from birth to 12 wk of age. Plasma (baseline) cortisol and ACTH concentrations were measured in 13 healthy foals at birth and at 1, 2, 3, 4, 5, 7, 10, 14, 21, 28, 42, 56, and 84 d of age. Each foal received cosyntropin (0.1 microg/kg) intravenously. Plasma cortisol concentrations were measured before (baseline), and 30, and 60 min after cosyntropin administration at birth and at 3, 5, 7, 10, 14, 21, 28, 42, 56, and 84 d of age. Compared with baseline, cortisol concentration increased significantly 30 min after administration of cosyntropin on all days. Cortisol concentration was highest at birth, measured at 30 and 60 min after cosyntropin administration, compared with all other days. With the exception of birth measurements, cortisol concentration was significantly higher on day 84, measured at 30 and 60 min after cosyntropin administration, when compared with all other days. Baseline plasma ACTH was lowest at birth when compared with concentrations on days 2, 3, 4, 5, 7, 10, 14, 42, 56, and 84. Administration of 0.1 microg/kg of cosyntropin, IV, reliably induces cortisol secretion in healthy foals. Differences in the magnitude of response to cosyntropin are observed depending on the age of the foal. These data should serve as a reference for the ACTH stimulation test in foals and should be useful in subsequent studies to evaluate the hypothalamic-pituitary-adrenal axis in healthy and critically ill foals.
本研究的目的是调查出生至12周龄马驹的血浆皮质醇和促肾上腺皮质激素（ACTH）的总基线浓度，以及ACTH刺激后的皮质醇浓度。在13匹健康马驹出生时以及出生后1、2、3、4、5、7、10、14、21、28、42、56和84日龄时测量血浆（基线）皮质醇和ACTH浓度。每匹马驹静脉注射促肾上腺皮质激素（0.1μg/kg）。在出生时以及出生后3、5、7、10、14、21、28、42、56和84日龄时，于注射促肾上腺皮质激素前（基线）以及注射后30和60分钟测量血浆皮质醇浓度。与基线相比，在所有测量日，注射促肾上腺皮质激素后30分钟皮质醇浓度均显著升高。与所有其他日期相比，出生时以及注射促肾上腺皮质激素后30和60分钟测量的皮质醇浓度最高。除出生时的测量值外，与所有其他日期相比，在84日龄时注射促肾上腺皮质激素后30和60分钟测量的皮质醇浓度显著更高。与出生后第2、3、4、5、7、10、14、42、56和84日的浓度相比，出生时的基线血浆ACTH最低。静脉注射0.1μg/kg促肾上腺皮质激素可可靠地诱导健康马驹分泌皮质醇。根据马驹的年龄，观察到对促肾上腺皮质激素反应强度的差异。这些数据应为马驹的ACTH刺激试验提供参考，并有助于后续研究评估健康和危重病马驹的下丘脑-垂体-肾上腺轴。
