Hamel-Jolette Avril, Dunn Marilyn, Bédard Christian
Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Québec, Canada.
Can J Vet Res. 2009 Jan;73(1):73-6.
Plateletworks is a screening assay used in human medicine to monitor platelet-inhibiting drugs. As arterial thromboembolism is a common complication in cats suffering from cardiomyopathy, they are often treated with anti-platelet medication. Clopidogrel (Plavix), an anti-platelet aggregation drug, has recently been evaluated in healthy cats. The purpose of this study was to determine if the Plateletworks method can detect a decrease in platelet aggregation in cats receiving clopidogrel. Nine healthy adult cats were used for this study. Platelet aggregation was measured before and after a 3-day clopidogrel treatment (18.75 mg SID). Platelet aggregation after the clopidogrel treatment was significantly lower (P < 0.01). The Plateletworks method appears to be a promising test to monitor clopidogrel therapy in cats.
血小板功能检测（Plateletworks）是一种用于人类医学监测血小板抑制药物的筛查试验。由于动脉血栓栓塞是患有心肌病的猫常见的并发症，它们经常接受抗血小板药物治疗。氯吡格雷（波立维），一种抗血小板聚集药物，最近已在健康猫身上进行了评估。本研究的目的是确定血小板功能检测方法能否检测出接受氯吡格雷治疗的猫血小板聚集的降低。九只健康成年猫用于本研究。在氯吡格雷治疗3天（18.75毫克，每日一次）前后测量血小板聚集。氯吡格雷治疗后的血小板聚集显著降低（P < 0.01）。血小板功能检测方法似乎是监测猫氯吡格雷治疗的一种有前景的试验。
