Departments of Neurology. National Institute of Neurology and Neurosurgery of Mexico. Insurgentes Sur 3877 Colonia La Fama Delegación Tlalpan México, Distrito Federal México.
Neuropsychiatr Dis Treat. 2008 Dec;4(6):1235-9. doi: 10.2147/ndt.s3990.
Different factors have been related with interictal anxiety, reported in 10%-25% of patients with epilepsy. We determined the frequency of interictal anxiety in 196 patients with active epilepsy in a cross-sectional survey to know which symptoms of anxiety were most frequently reported in patients with epilepsy and to analyze the factors associated with their presence. Patients were assessed with the Beck Depression Inventory (BDI), Montgomery-Asberg Depression Rating Scale (MADRS), and the Hamilton Anxiety Scale (HAMA). Data were analyzed with a logistic regression model. The HAMA ratings revealed that 38.8% experienced significant anxiety symptoms, as defined by a rating above 18 points. Use of primidone, depression, cryptogenic, and posttraumatic etiologies significantly predicted anxiety after logistic regression. Symptoms related to higher scores on HAMA were anxious mood, tension, insomnia, intellectual function, depressed mood, cardiovascular and genitourinary symptoms. Further studies should be performed to define the role of psychosocial factors in the development and evolution of anxiety among these patients.
不同的因素与癫痫发作间期焦虑有关，在 10%-25%的癫痫患者中都有报道。我们通过横断面调查确定了 196 例活动性癫痫患者的发作间期焦虑频率，以了解癫痫患者最常报告的焦虑症状，并分析与焦虑存在相关的因素。患者使用贝克抑郁量表 (BDI)、蒙哥马利-阿斯伯格抑郁评定量表 (MADRS) 和汉密尔顿焦虑量表 (HAMA) 进行评估。数据采用逻辑回归模型进行分析。HAMA 评分显示，38.8%的患者存在明显的焦虑症状，定义为评分高于 18 分。使用扑米酮、抑郁、隐源性和创伤后病因在逻辑回归后显著预测焦虑。与 HAMA 评分较高相关的症状包括焦虑情绪、紧张、失眠、智力功能、抑郁情绪、心血管和泌尿生殖系统症状。应进一步开展研究，以明确这些患者中焦虑发生和发展的心理社会因素的作用。
