Ramos-Mondragón Roberto, Galindo Carlos A, Avila Guillermo
Departamento de Bioquímica, Cinvestav-IPN, México.
Vasc Health Risk Manag. 2008;4(6):1289-300. doi: 10.2147/vhrm.s3985.
The type beta transforming growth factors (TGF-betas) are involved in a number of human diseases, including heart failure and myocardial arrhythmias. In fact, during the last 20 years numerous studies have demonstrated that TGF-beta affects the architecture of the heart under both normal and pathological conditions. Moreover, TGF-beta signaling is currently under investigation, with the aim of discovering potential therapeutic roles in human disease. In contrast, only few studies have investigated whether TGF-beta affects electrophysiological properties of the heart. This fact is surprising since electrical remodeling represents an important substrate for cardiac disease. This review discusses the potential role of TGF-beta on cardiac excitation-contraction (EC) coupling, action potentials, and ion channels. We also discuss the effects of TGF-beta on cardiac development and disease from structural and electrophysiological points of view.
β型转化生长因子（TGF-βs）与多种人类疾病有关，包括心力衰竭和心肌心律失常。事实上，在过去20年中，大量研究表明，TGF-β在正常和病理条件下都会影响心脏结构。此外，目前正在对TGF-β信号传导进行研究，目的是发现其在人类疾病中的潜在治疗作用。相比之下，只有少数研究调查了TGF-β是否会影响心脏的电生理特性。鉴于电重构是心脏病的一个重要基础，这一事实令人惊讶。本综述讨论了TGF-β在心脏兴奋-收缩（EC）偶联、动作电位和离子通道方面的潜在作用。我们还从结构和电生理角度讨论了TGF-β对心脏发育和疾病的影响。
