Department of Pathology, Son LLatzer Hospital, Carretera de Manacor, km.4. Palma de Mallorca, Spain.
J Gastrointestin Liver Dis. 2009 Mar;18(1):89-93.
Synovial sarcoma (SS) is an uncommon malignant neoplasm of the soft tissues. It mainly affects the periarticular tissues of the extremities in young adults, but has been described at nearly all sites; nevertheless, the gastrointestinal tract is an exceptional location. We report a case of a primary synovial sarcoma of the duodenum in a 69-year-old woman. Histological study showed a monophasic pattern. The tumor cells demonstrated diffuse vimentin and Bcl-2 expression, partial EMA expression and focal AE1/3 positivity. The differential diagnosis includes gastrointestinal stromal tumors. Cytogenetic analysis confirmed the diagnosis, with detection of the X;18 translocation. The patient presented postoperative complications and died one month following the intervention.
滑膜肉瘤（SS）是一种罕见的软组织恶性肿瘤。它主要影响年轻成年人四肢的关节周围组织，但几乎可以发生在所有部位；然而，胃肠道是一个特殊的部位。我们报告了一例 69 岁女性十二指肠原发性滑膜肉瘤。组织学研究显示为单相模式。肿瘤细胞弥漫表达波形蛋白和 Bcl-2，部分表达 EMA，局灶性 AE1/3 阳性。鉴别诊断包括胃肠道间质瘤。细胞遗传学分析证实了这一诊断，检测到 X;18 易位。患者术后出现并发症，并在干预后一个月死亡。
