Horder Jamie, Cowen Philip J, Di Simplicio Martina, Browning Michael, Harmer Catherine J
University Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Psychopharmacology (Berl). 2009 Jul;205(1):85-91. doi: 10.1007/s00213-009-1517-4. Epub 2009 Apr 1.
Emotional processing measures are sensitive to acute administration of clinically useful antidepressant drugs. We wished to test the hypothesis that these models would also be able to detect agents likely to cause depression as an adverse effect. The anti-obesity drug and cannabinoid type 1 receptor antagonist, rimonabant, is associated with significant rates of depression and anxiety in clinical use.
Thirty healthy adult volunteers were randomly assigned to receive a single dose of rimonabant (20 mg) or lactose placebo in a double-blind, between-groups design. Three hours after medication administration, subjects undertook an emotional processing test battery including facial emotion recognition, emotional word attentional dot probe, self-relevant word classification, emotional and declarative memory and the emotion-potentiated acoustic startle response. Subjective state was assessed via self-report measures.
A single dose of rimonabant did not alter subjective mood. However, rimonabant selectively reduced incidental recall of positive self-relevant adjectives, an effect contrary to that seen following the administration of antidepressants. There were no effects of rimonabant on the other measures of emotional processing.
These results suggest that a single dose of rimonabant decreases positive emotional memory in the absence of changes in subjective state. Further studies are required to examine whether rimonabant might produce a wider range of negative emotional biases with repeated treatment.
情绪加工测量对临床上有用的抗抑郁药物的急性给药敏感。我们希望检验这样一个假设，即这些模型也能够检测出可能导致抑郁作为不良反应的药物。抗肥胖药物和大麻素1型受体拮抗剂利莫那班在临床使用中与显著的抑郁和焦虑发生率相关。
30名健康成年志愿者被随机分配，在双盲组间设计中接受单剂量利莫那班（20毫克）或乳糖安慰剂。给药三小时后，受试者进行了一系列情绪加工测试，包括面部情绪识别、情绪词汇注意力点探测、自我相关词汇分类、情绪和陈述性记忆以及情绪增强的听觉惊吓反应。通过自我报告测量评估主观状态。
单剂量利莫那班未改变主观情绪。然而，利莫那班选择性地降低了对积极自我相关形容词的偶然回忆，这一效果与服用抗抑郁药后的情况相反。利莫那班对其他情绪加工测量没有影响。
这些结果表明，单剂量利莫那班在主观状态无变化的情况下会降低积极情绪记忆。需要进一步研究来检验利莫那班在重复治疗时是否可能产生更广泛的负面情绪偏差。
