Zhang Hai-Feng, Qiu Li-Xin, Chen Yu, Zhu Wa-Li, Mao Chen, Zhu Li-Guang, Zheng Ming-Hua, Wang Yan, Lei Lei, Shi Jian
Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Hum Genet. 2009 Jun;125(5-6):627-31. doi: 10.1007/s00439-009-0660-7. Epub 2009 Apr 1.
Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn's disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians (P < 0.01). The pooled estimations of OR(1) (GG vs. AA) and OR(2) (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69-2.05] and (1.39, 95% CI 1.27-1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.
许多研究报告了自噬相关16样蛋白1基因（ATG16L1）T300A多态性（rs2241880）与克罗恩病（CD）易感性之间的关联，但结果尚无定论。为了更精确地评估二者关系，我们进行了一项荟萃分析。该荟萃分析共纳入24项研究，包括13,022例病例和17,532例对照。逻辑回归分析表明，ATG16L1 T300A多态性与白种人中CD风险相关（P < 0.01）。采用贝叶斯荟萃分析方法对白种人研究中OR(1)（GG vs. AA）和OR(2)（GA vs. AA）的合并估计值分别为[1.87，95%置信区间（CI）1.69 - 2.05]和（1.39，95% CI 1.27 - 1.51）。在白种人中，G等位基因的遗传模式最有可能是共显性的。然而，在亚洲人中未发现显著关联。这项荟萃分析表明，ATG16L1 T300A的G等位基因是白种人中导致CD的一个低外显率基因。
