Maccarrone Mauro
University of Teramo, Department of Biomedical Sciences, Piazza A Moro 45, 64100 Teramo, Italy.
Curr Opin Investig Drugs. 2009 Apr;10(4):305-10.
The endocannabinoids anandamide and 2-arachidonoylglycerol mimic Delta9-tetrahydrocannabinol, the chemical component responsible for the psychoactive properties of Cannabis sativa, by binding to both type 1 and type 2 cannabinoid receptors. Endocannabinoids exert several actions, both centrally and peripherally, and are synthesized or hydrolyzed by specific enzymes. In this review, the elements that constitute the endocannabinoid system (ECS) are described, with the aim of describing their interplay with other components of reproductive endocrinology, both in females and males. In particular, the interaction of the ECS with sex hormones and cytokines,1 generating an endocannabinoid/hormone/cytokine array responsible for the control of human fertility, is discussed. The data for endocannabinoids suggest that these molecules can be proposed as novel lipid hormones (lipokines) that are critically involved in reproductive events.
内源性大麻素花生四烯乙醇胺和2-花生四烯酸甘油酯通过与1型和2型大麻素受体结合，模拟Δ9-四氢大麻酚，后者是负责大麻精神活性的化学成分。内源性大麻素在中枢和外周发挥多种作用，并由特定酶合成或水解。在本综述中，描述了构成内源性大麻素系统（ECS）的元素，目的是描述它们与生殖内分泌学其他成分在女性和男性中的相互作用。特别是，讨论了ECS与性激素和细胞因子的相互作用，1产生了负责控制人类生育能力的内源性大麻素/激素/细胞因子阵列。内源性大麻素的数据表明，这些分子可被认为是在生殖事件中起关键作用的新型脂质激素（脂动素）。
