Transfer of resistance to selective conditions from fibroblasts with mutant feedback-resistant phosphoribosylpyrophosphate synthetase to normal cells. A form of metabolic cooperation.
作者信息
Zoref E, de Vries A, Sperling O
出版信息
Adv Exp Med Biol. 1977;76A:80-4. doi: 10.1007/978-1-4613-4223-6_10.
PMID:193380
Abstract
摘要
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Transfer of resistance to selective conditions from fibroblasts with mutant feedback-resistant phosphoribosylpyrophosphate synthetase to normal cells. A form of metabolic cooperation.
Adv Exp Med Biol. 1977;76A:80-4. doi: 10.1007/978-1-4613-4223-6_10.
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X-linked pattern of inheritance of gout due to mutant feedback-resistant phosphoribosylpyrophosphate synthetase.
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Overproduction disease in man due to enzyme feedback resistance mutation. Purine overproduction in gout due to excessive activity of mutant feedback-resistant phosphoribosylpyrophosphate synthetase.由于酶反馈抗性突变导致的人类过量生产疾病。痛风中嘌呤过量产生是由于突变的反馈抗性磷酸核糖焦磷酸合成酶活性过高。
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Superactivity of phosphoribosylpyrophosphate synthetase, due to feedback resistance, causing purine overproduction and gout.由于反馈抗性导致磷酸核糖焦磷酸合成酶活性过高，引起嘌呤过度产生和痛风。
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Phosphoribosylpyrophosphate synthetase is elevated in fibroblasts from patients with the Lesch-Nyhan syndrome.磷酸核糖焦磷酸合成酶在莱施-奈恩综合征患者的成纤维细胞中升高。
Science. 1976 Jul 30;193(4251):408-11. doi: 10.1126/science.180603.
8
Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblasts.与嘌呤过量生成和痛风相关的突变型反馈抗性磷酸核糖焦磷酸合成酶。培养成纤维细胞中的磷酸核糖焦磷酸和嘌呤代谢。
J Clin Invest. 1975 Nov;56(5):1093-9. doi: 10.1172/JCI108183.
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Phosphoribosylpyrophosphate (PRPP) synthetase mutant in Salmonella typhimurium.
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Evidence for X-linkage of phosphoribosylpyrophosphate synthetase in man. Studies with cultured fibroblasts from a gouty family with mutant feedback-resistant enzyme.
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