Zosimovskiĭ V A, Korshunov V A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2009 Jan-Feb;59(1):87-97.
In agreement with existing notion, in a waking animal, novel information during learning transfers from the neocortex to the hippocampus where creates a transient trace in the form of a distributed pattern of modified synapses. During sleep, due to reactivation of neuronal populations initially activated by novel stimulus, this information flows back to the neocortex thus facilitating permanent memory trace consolidation. Information transfer between the neocortex and hippocampal formation is realized, in general, via the entorhinal cortex whose intrinsic connections basically permit "messages" from the exit of the hippocampal formation to return to its entrances. In waking and sleeping rats, we demonstrated a possibility of the return of the excitatory waves to hippocampal field CA1 and dentate gyrus via perforant path fibers that initially enter the CA1 via potentiated Schaffer collateral synapses. During sleep the returned excitatory waves were of maximal amplitude and with a high probability elicited a discharge of dentate neurons. Thus, a novel stimulus that potentiates synaptic connections during waking in the hippocampus and probably in the entorhinal cortex creates conditions for reactivation of corresponding neuronal populations in the hippocampus during sleep by excitatory waves returning via the entorhinal cortex.
与现有观点一致，在清醒动物中，学习过程中的新信息从新皮层传递到海马体，在海马体中以修饰突触的分布式模式形成短暂痕迹。在睡眠期间，由于最初由新刺激激活的神经元群的重新激活，这些信息回流到新皮层，从而促进永久记忆痕迹的巩固。一般来说，新皮层和海马结构之间的信息传递是通过内嗅皮层实现的，其内源性连接基本上允许“信息”从海马结构的出口返回其入口。在清醒和睡眠的大鼠中，我们证明了兴奋性波通过穿通路径纤维返回海马CA1区和齿状回的可能性，这些纤维最初通过增强的Schaffer侧支突触进入CA1区。在睡眠期间，返回的兴奋性波具有最大振幅，并且很可能引发齿状神经元的放电。因此，在清醒时增强海马体以及可能在内嗅皮层中突触连接的新刺激，通过经由内嗅皮层返回的兴奋性波，为睡眠期间海马体中相应神经元群的重新激活创造了条件。
