Liao Chun-Hou, Chung Shiu-Dong, Lai Ming-Kuen, Yu Hong-Jeng, Chueh Shih-Chieh
Division of Urology, Department of Surgery, Cardinal Tien Hospital, Fu Jen Catholic University, Hsin Chuang, Taiwan.
BJU Int. 2009 Nov;104(9):1269-73. doi: 10.1111/j.1464-410X.2009.08523.x. Epub 2009 Mar 30.
To examine the feasibility and safety of laparoscopic simultaneous bilateral adrenal surgery (LSBAS) and to compare the results between laparoscopic total adrenalectomy (TA) and partial adrenalectomy (PA).
Between 1999 and January 2008, 12 patients underwent LBAS in our institution, with TA used in four with Cushing's disease refractory to pituitary surgery or radiation, in one with occult ectopic adrenocorticotropic hormone (ACTH) Cushing's syndrome, and one with bilateral adrenal macronodular hyperplasia. Six patients (five with primary aldosteronism and one with Cushing's syndrome) had bilateral functioning tumours had bilateral PAs.
All 12 operations were completed with no intraoperative complication, conversion, re-operation or death. The mean (range) operative duration was 323 (180-560) min, and the mean estimated blood loss was 79 (20-200) mL. There was adrenal insufficiency after surgery in three patients. Patients who had a PA had significantly longer surgery than those treated with TA, with a mean (sd) of 390 (36) vs 255 (27) min.
LSBAS is technically feasible; although surgery was longer than TA, bilateral PA in patients with bilateral functioning tumours mitigated the need for life-long steroid replacement.
探讨腹腔镜同期双侧肾上腺手术(LSBAS)的可行性和安全性,并比较腹腔镜全肾上腺切除术(TA)和肾上腺部分切除术(PA)的效果。
1999年至2008年1月期间,我院有12例患者接受了LSBAS,其中4例库欣病患者因垂体手术或放疗无效而行TA,1例隐匿性异位促肾上腺皮质激素(ACTH)库欣综合征患者和1例双侧肾上腺大结节增生患者行TA。6例(5例原发性醛固酮增多症和1例库欣综合征)双侧功能性肿瘤患者行双侧PA。
12例手术均顺利完成,无术中并发症、中转手术、再次手术或死亡。平均(范围)手术时间为323(180 - 560)分钟,平均估计失血量为79(20 - 200)毫升。3例患者术后出现肾上腺功能不全。行PA的患者手术时间明显长于行TA的患者,平均(标准差)分别为390(36)分钟和255(27)分钟。
LSBAS在技术上是可行的;虽然手术时间比TA长,但双侧功能性肿瘤患者行双侧PA可减少终身激素替代治疗的需求。