镀铬金属制品可能会对患有铬酸盐过敏症的患者造成危害。
Chromated metal products may be hazardous to patients with chromate allergy.
作者信息
Geier Johannes, Lessmann Holger, Hellweg Brigitte, Jappe Uta, Spornraft-Ragaller Petra, Fuchs Thomas, Aberer Werner, Frosch Peter J, Weisshaar Elke, Mahler Vera, Löffler Harald, Skudlik Christoph, Szliska Christiane, Koch Patrick, Pföhler Claudia, Lilie Martina, Becker Detlef, Trcka Jiri, Meyer Jochen, Hahn Jens-Uwe, Adam Monika
机构信息
Information Network of Departments of Dermatology, University of Göttingen, 37075 Göttingen, Germany.
出版信息
Contact Dermatitis. 2009 Apr;60(4):199-202. doi: 10.1111/j.1600-0536.2008.01476.x.
BACKGROUND
Hidden allergen exposure may contribute to persistence and relapse of chromate dermatitis. According to case reports, chromated metal products, such as screws, fittings, etc., may be relevant allergen sources for patients sensitized to chromate.
OBJECTIVES
To examine concomitant patch test reactivity to potassium dichromate 0.5% petrolatum (pet.) and three different types of chromated metal rings.
PATIENTS/METHODS: Patients with proven or suspected chromate allergy were patch tested with potassium dichromate 0.5% pet. and three different types of chromated metal rings (yellow, olive, and black). Hexavalent chromium Cr(VI) release from the patch tested rings was chemically analysed.
RESULTS
Ninety-five patients were tested: 49/95 (52%) reacted to potassium dichromate and 25/95 (26%) reacted to black chromated rings. Reactions to chromated rings exclusively occurred in patients reacting to potassium dichromate. Of 20 patients with a strong reaction to potassium dichromate, 14 reacted to black chromated rings. These were shown to have a high Cr(VI) release. Only two patients reacted to the other chromated rings, which had a very low Cr(VI) release.
CONCLUSIONS
Handling chromated metal products must be regarded a hazard to chromate-sensitive patients, in particular those with a strong sensitization.
背景
隐匿性变应原暴露可能导致铬酸盐皮炎的持续存在和复发。根据病例报告，铬酸盐金属制品，如螺钉、配件等，可能是对铬酸盐致敏患者的相关变应原来源。
目的
检测对0.5%凡士林（pet.）重铬酸钾和三种不同类型铬酸盐金属环的斑贴试验反应性。
患者/方法：对已证实或疑似铬酸盐过敏的患者进行0.5% pet.重铬酸钾和三种不同类型铬酸盐金属环（黄色、橄榄色和黑色）的斑贴试验。对斑贴试验环中六价铬Cr(VI)的释放进行化学分析。
结果
共检测了95例患者：49/95（52%）对重铬酸钾有反应，25/95（26%）对黑色铬酸盐环有反应。对铬酸盐环的反应仅发生在对重铬酸钾有反应的患者中。在20例对重铬酸钾有强烈反应的患者中，14例对黑色铬酸盐环有反应。这些环显示出高Cr(VI)释放。只有2例患者对其他铬酸盐环有反应，这些环的Cr(VI)释放非常低。
结论
对于对铬酸盐敏感的患者，尤其是那些高度致敏的患者，处理铬酸盐金属制品必须被视为一种危险因素。
Zotero 插件