组织蛋白酶K：骨疾病的治疗靶点。
Cathepsin K: a therapeutic target for bone diseases.
作者信息
Zhao Qingxiao, Jia Yanping, Xiao Yongtao
机构信息
College of Chemical Engineering, Northeast Dianli University, Jilin, PR China.
出版信息
Biochem Biophys Res Commun. 2009 Mar 20;380(4):721-3. doi: 10.1016/j.bbrc.2009.01.139. Epub 2009 Jan 27.
PMID:19338743
Abstract
Cathepsin K is a member of the papain family of cysteine proteases and is highly expressed in osteoclasts that mediate bone resorption. In this review, some of the known features of cathepsin K such as structure, function in bone resorption, gene regulation and its roles in physiological or pathophysiological processes are highlighted.
摘要
组织蛋白酶K是半胱氨酸蛋白酶木瓜蛋白酶家族的成员，在介导骨吸收的破骨细胞中高度表达。在本综述中，重点介绍了组织蛋白酶K的一些已知特征，如结构、在骨吸收中的功能、基因调控及其在生理或病理生理过程中的作用。
Zotero 插件