Belmontesi Magda, Grover Rajiv, Verpaele Alexis
Aesthet Surg J. 2006 Jan-Feb;26(1S):S28-34. doi: 10.1016/j.asj.2005.10.002.
Initial experience in transdermal administration of Restylane SubQ for augmentation of the cheek and chin suggests that the product is easy to administer via this route and that it provides a stable aesthetic result. Local adverse reactions are consistent with those expected of an alloplastic filler material and appear to be related to the injection procedure/site rather than to the product itself. In the event of overcorrection or the appearance of superficial irregularities (nodules), any excess material can readily be removed by needle aspiration. Several measures can be taken to increase the likelihood of a satisfactory aesthetic outcome and minimize the risk of treatment complications with Restylane SubQ. One such measure is to deposit the product in small aliquots at multiple sites (using a multiple tunneling technique) to avoid pooling within the soft tissues. Treatment sites with poor soft-tissue cover pose a challenge because of the high risk of surface irregularities. In cheek augmentation procedures, Restylane SubQ should be placed below the zygomatic arch where the subcutaneous tissue is more fibrous, thereby providing a possible barrier to implant mobility. The chin appears to be particularly well suited to volume augmentation with Restylane SubQ because its dense fibrous tissue creates naturally occurring pockets for product placement. In summary, transdermal administration of Restylane SubQ is a convenient, noninvasive procedure for chin and cheek contouring and for rejuvenation of the mid and lower face.
瑞蓝SubQ经皮给药用于丰颊和隆颏的初步经验表明，该产品通过此途径易于给药，且能提供稳定的美学效果。局部不良反应与预期的异质填充材料的不良反应一致，似乎与注射操作/部位有关，而非与产品本身有关。若出现矫正过度或表面不规则（结节），可通过针吸轻松去除多余材料。可采取多种措施提高获得满意美学效果的可能性，并将使用瑞蓝SubQ治疗的并发症风险降至最低。其中一项措施是在多个部位以小剂量分注产品（采用多隧道技术），以避免在软组织内积聚。软组织覆盖较差的治疗部位因表面不规则风险高而具有挑战性。在丰颊手术中，瑞蓝SubQ应置于颧弓下方，此处皮下组织纤维更多，从而为植入物移动提供可能的屏障。颏部似乎特别适合用瑞蓝SubQ进行容积增加，因为其致密的纤维组织为产品植入创造了天然的腔隙。总之，瑞蓝SubQ经皮给药是一种用于颏部和颊部轮廓塑形以及中下面部年轻化的便捷、非侵入性手术。
