Department of Clinical Medicine, University of Palermo, Palermo, Italy.
Fertil Steril. 2010 Jun;94(1):194-7. doi: 10.1016/j.fertnstert.2009.02.056. Epub 2009 Apr 1.
To verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual irregularities, infertility, central obesity, acanthosis nigricans, rapid progression of the hirsutism, clitoromegaly) should not be further studied.
Retrospective study in patients referred because of mild hirsutism and no other clinical signs.
Department of Clinical Medicine of the University of Palermo.
PATIENT(S): One hundred fifty-two patients with mild hirsutism.
INTERVENTION(S): Measurement of serum testosterone, dehydroepiandrosterone sulfate, 17-OH-Progesterone, assessment of ovulation by measurement of progesterone in 21 to 24 days and ovarian ultrasound.
RESULT(S): In 72 (47%) patients a diagnosis of polycyctic ovarian syndrome (PCOS) was performed. Polycyctic ovarian syndrome patients included 56 patients with the mild ovulatory form (OV-PCOS) but also 16 patients with the anovulatory form (classic PCOS). Three (2%) patients had nonclassic adrenal hyperplasia.
CONCLUSION(S): Because of the high prevalence of PCOS and the possibility of finding nonclassic 21-hydroxylase deficiency, patients with mild hirsutism need a diagnostic evaluation that should include 17-hydroxyprogesterone measurement plus assessment of ovulation and ovarian ultrasound.
验证内分泌学会指南的结论，即患有轻度多毛症且没有其他重要临床体征（月经不规律、不孕、中心性肥胖、黑棘皮病、多毛症快速进展、阴蒂肥大）的患者不应进一步研究。
对因轻度多毛症且无其他临床体征而就诊的患者进行回顾性研究。
巴勒莫大学临床医学系。
152 例轻度多毛症患者。
测量血清睾酮、硫酸脱氢表雄酮、17-羟孕酮，通过测量 21-24 天的孕激素评估排卵，并进行卵巢超声检查。
72 例（47%）患者诊断为多囊卵巢综合征（PCOS）。多囊卵巢综合征患者包括 56 例轻度排卵型（OV-PCOS）和 16 例无排卵型（经典 PCOS）。3 例（2%）患者存在非经典肾上腺增生。
由于 PCOS 的高发率和发现非经典 21-羟化酶缺乏的可能性，轻度多毛症患者需要进行诊断评估，包括 17-羟孕酮测量、排卵评估和卵巢超声检查。
