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不孕患者希望停止储存时对冷冻胚胎的处理。

Disposition of cryopreserved embryos by infertility patients desiring to discontinue storage.

机构信息

Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8513, Suite 3100, 4444 Forest Park Avenue, St. Louis, Missouri 63108, USA.

出版信息

Fertil Steril. 2010 Feb;93(2):486-9. doi: 10.1016/j.fertnstert.2009.02.001. Epub 2009 Mar 31.

Abstract

OBJECTIVE

To review our patients' decisions for disposition of their cryopreserved embryos and compare the findings with those reported in the scientific literature. Patients who no longer wish to store their cryopreserved embryos have three choices: discarding, donation to research, or donation to someone else for initiation of a pregnancy.

DESIGN

Retrospective review of patient records from January 2002 to July 2007 to determine preferences for embryo disposition.

SETTING

University hospital.

PATIENT(S): Patients who elected to discontinue embryo cryostorage.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Patients' decisions regarding embryo disposition, length of storage, treatment outcome, age at oocyte retrieval, and age at time of disposition.

RESULT(S): A total of 149 disposition requests were reviewed, with 59% donating to scientific research, 38% discarding, and 3% donating to a known or anonymous person/couple for attempted pregnancy. There was no significant difference in the choice selected between patients who achieved a pregnancy with delivery compared with those who did not. Patient age at retrieval and at the time of disposition as well as the total time in storage was not significantly different between patients electing to discard and those donating to research.

CONCLUSION(S): Patients in our program wanting to discontinue cryostorage were more likely to request that their surplus embryos be used for scientific research.

摘要

目的

回顾我们的患者对其冷冻胚胎处置方式的决定,并与科学文献中的报道进行比较。不再希望储存冷冻胚胎的患者有三种选择:丢弃、捐赠给研究、或捐赠给他人以启动妊娠。

设计

回顾 2002 年 1 月至 2007 年 7 月的患者病历,以确定胚胎处置偏好。

地点

大学医院。

患者

选择停止胚胎冷冻储存的患者。

干预措施

无。

主要观察指标

患者对胚胎处置、储存时间、治疗结局、卵母细胞采集时的年龄以及处置时的年龄的决定。

结果

共回顾了 149 份处置请求,其中 59%的患者选择将胚胎捐赠给科学研究,38%的患者选择丢弃,3%的患者选择将胚胎捐赠给已知或匿名的个人/夫妇以尝试妊娠。与成功妊娠并分娩的患者相比,未成功妊娠的患者在选择方面没有显著差异。选择丢弃胚胎和捐赠给研究的患者的年龄在采集和处置时以及总储存时间上没有显著差异。

结论

我们的方案中希望停止冷冻储存的患者更倾向于要求将其多余的胚胎用于科学研究。

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