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Cysteine proteinase type III is protective against Leishmania infantum infection in BALB/c mice and highly antigenic in visceral leishmaniasis individuals.III型半胱氨酸蛋白酶对BALB/c小鼠的婴儿利什曼原虫感染具有保护作用，并且在内脏利什曼病患者中具有高度抗原性。
Vaccine. 2008 Oct 29;26(46):5822-9. doi: 10.1016/j.vaccine.2008.08.065. Epub 2008 Sep 18.
2
Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein.用重组A2蛋白免疫的比格犬对恰加斯利什曼原虫（利什曼原虫）攻击的保护性免疫。
Vaccine. 2008 Oct 29;26(46):5888-95. doi: 10.1016/j.vaccine.2008.05.095. Epub 2008 Sep 9.
3
Contrasting human cytokine responses to promastigote whole-cell extract and the Leishmania analogue receptor for activated C kinase antigen of L. amazonensis in natural infection versus immunization.对比人类细胞因子对前鞭毛体全细胞提取物以及亚马逊利什曼原虫中活化C激酶抗原的利什曼原虫类似受体在自然感染与免疫过程中的反应。
Clin Exp Immunol. 2008 Sep;153(3):369-75. doi: 10.1111/j.1365-2249.2008.03705.x. Epub 2008 Jul 8.
4
Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: correlation with IFN-gamma and cytolytic activity by CD8+ T cells.表达利什曼原虫无鞭毛体特异性A2抗原的腺病毒引发的表位作图和保护性免疫：与IFN-γ及CD8 + T细胞的细胞溶解活性的相关性
Vaccine. 2008 Aug 18;26(35):4585-93. doi: 10.1016/j.vaccine.2008.05.091. Epub 2008 Jun 25.
5
Comparative evaluation of direct agglutination test, rK39 and soluble antigen ELISA and IFAT for the diagnosis of visceral leishmaniasis.用于内脏利什曼病诊断的直接凝集试验、rK39和可溶性抗原酶联免疫吸附测定以及间接荧光抗体试验的比较评估
Trans R Soc Trop Med Hyg. 2008 Feb;102(2):172-8. doi: 10.1016/j.trstmh.2007.11.004. Epub 2007 Dec 26.
6
Cutaneous leishmaniasis.皮肤利什曼病
Lancet Infect Dis. 2007 Sep;7(9):581-96. doi: 10.1016/S1473-3099(07)70209-8.
7
Immune response and protection assay of recombinant major surface glycoprotein of Leishmania (rgp63) reconstituted with liposomes in BALB/c mice.利什曼原虫重组主要表面糖蛋白（rgp63）脂质体重构物在BALB/c小鼠中的免疫应答及保护试验
Vaccine. 2006 Jul 17;24(29-30):5708-17. doi: 10.1016/j.vaccine.2006.04.062. Epub 2006 May 11.
8
Field validity, reproducibility and feasibility of diagnostic tests for visceral leishmaniasis in rural Nepal.尼泊尔农村内脏利什曼病诊断检测的现场有效性、可重复性及可行性
Trop Med Int Health. 2006 Jan;11(1):31-40. doi: 10.1111/j.1365-3156.2005.01533.x.
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LmxPK4, a mitogen-activated protein kinase kinase homologue of Leishmania mexicana with a potential role in parasite differentiation.LmxPK4，一种墨西哥利什曼原虫的丝裂原活化蛋白激酶激酶同源物，在寄生虫分化中可能发挥作用。
Mol Microbiol. 2005 Jun;56(5):1169-82. doi: 10.1111/j.1365-2958.2005.04614.x.
10
Analysis of granzyme B activity as a surrogate marker of Leishmania-specific cell-mediated cytotoxicity in zoonotic cutaneous leishmaniasis.分析颗粒酶B活性作为人兽共患皮肤利什曼病中利什曼原虫特异性细胞介导细胞毒性的替代标志物。
J Infect Dis. 2004 Apr 1;189(7):1265-73. doi: 10.1086/382031. Epub 2004 Mar 12.

治愈的皮肤利什曼病和地中海内脏利什曼病患者对硕大利什曼原虫毒力因子的细胞和体液反应。

Cellular and humoral responses to Leishmania major virulence factors in healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients.

作者信息

Lakhal-Naouar Inès, Boussoffara Thouraya, Meddeb-Garnaoui Amel, Ben Achour-Chenik Yosser, Louzir Hechmi, Chenik Mehdi

机构信息

Institut Pasteur de Tunis, BP 74, 13, Place Pasteur, 1002 Tunis, Tunisia.

出版信息

Clin Vaccine Immunol. 2009 Jun;16(6):956-8. doi: 10.1128/CVI.00023-09. Epub 2009 Apr 1.

DOI:10.1128/CVI.00023-09
PMID:19339488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2691049/
Abstract

Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase (MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.

摘要

针对利什曼原虫主要毒力蛋白——利什曼原虫主要蛋白二硫键异构酶（LmPDI）和丝裂原活化蛋白激酶激酶（MAPKK）的检测结果，对已治愈的皮肤利什曼病和地中海内脏利什曼病患者的细胞免疫和体液免疫反应进行了评估。只有MAPKK能诱导外周血单核细胞显著增殖，并产生γ干扰素以及引发抗体反应。因此，MAPKK可能在利什曼原虫疫苗接种和血清学诊断方面具有研究价值。