Sakai K, Ueyama A, Kishino Y
Department of Nutrition, School of Medicine, University of Tokushima, Japan.
Cell Mol Biol. 1991;37(4):475-80.
Phagocytic activity of alveolar macrophages (AM) was enhanced by pulmonary surfactant obtained from bronchoalveolar lavage fluid of rats starved for 2 days, as compared to fed. The enhanced activity of phagocytosis was dependent on the dose of surfactant. The prepared surfactant showed a different protein to phospholipid ratio of 0.108 in fed and 0.234 in 2 days starved, because of an increased ratio of protein in surfactant from 2 days starved rats. F(ab')2 anti-surfactant protein inhibited the enhanced AM phagocytosis by surfactant. These results suggested that the enhancement of AM phagocytosis in 2 days starved rats was on account of an increase of protein in their surfactant compared to fed.
与喂食大鼠相比，从饥饿2天的大鼠支气管肺泡灌洗液中获得的肺表面活性物质可增强肺泡巨噬细胞（AM）的吞噬活性。吞噬活性的增强取决于表面活性物质的剂量。制备的表面活性物质在喂食大鼠中显示出不同的蛋白质与磷脂比率，即0.108，而在饥饿2天的大鼠中为0.234，这是因为饥饿2天大鼠的表面活性物质中蛋白质比率增加。F(ab')2抗表面活性物质蛋白可抑制表面活性物质增强的AM吞噬作用。这些结果表明，与喂食大鼠相比，饥饿2天大鼠的AM吞噬作用增强是由于其表面活性物质中蛋白质增加所致。
