Park E
Am J Phys Anthropol. 1977 May;46(3):455-61. doi: 10.1002/ajpa.1330460311.
Cortical bone width measurements taken at midshaft on the second metacarpal were obtained from 156 hand X-rays of 80 karyotypically documented individuals with Turner's syndrome age 1 to 25 years. Total shaft width, medullary width, cortical width and percent cortical area were grouped by bone age and compared with normal female standards. Total width was significantly and increasingly below normal; medullary width was not consistently different from normal; cortical width was significantly lower from normal from age 14 onward, although it did rise at age 17 (adult bone age); percent cortical area was significantly below normal at ages 14 and 15, but was normal by adulthood. Values for percent cortical area did not indicate severe or widespread osteoporosis. Within the Turners sample cortical bone measurement were not significantly decreased in the presence of the XO sex chromosome constitution compared with other sex chromosome variants. Nor were the measurements decreased in the presence of positive metacarpal sign or a combination of typical Turner stigmata (web neck, low posterior hairline, shield chest). There was evidence that cortical width and percent cortical area increased significantly following estrogen treatment or spontaneous menarche.
从80名年龄在1至25岁、经染色体核型记录确诊为特纳综合征患者的156份手部X光片中，获取了第二掌骨骨干中部的皮质骨宽度测量数据。将骨干总宽度、髓腔宽度、皮质宽度和皮质面积百分比按骨龄分组，并与正常女性标准进行比较。骨干总宽度显著且逐渐低于正常水平；髓腔宽度与正常水平无一致差异；从14岁起，皮质宽度显著低于正常水平，不过在17岁（成人骨龄）时有所上升；皮质面积百分比在14岁和15岁时显著低于正常水平，但成年后恢复正常。皮质面积百分比数值并未表明存在严重或广泛的骨质疏松。在特纳综合征样本中，与其他性染色体变异相比，XO性染色体构成情况下皮质骨测量值并未显著降低。在存在掌骨阳性体征或典型特纳综合征体征（蹼颈、低后发际线、盾状胸）组合的情况下，测量值也未降低。有证据表明，雌激素治疗或自然月经初潮后，皮质宽度和皮质面积百分比显著增加。
