Saul'skaya N B, Fofonova N V
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St. Petersburg, Russia.
Neurosci Behav Physiol. 2009 May;39(4):335-40. doi: 10.1007/s11055-009-9145-3. Epub 2009 Apr 2.
Intracerebral microdialysis studies on Sprague-Dawley rats using HPLC showed that performance of a conditioned reflex fear reaction was accompanied by an increase in the extracellular citrulline (a co-product of nitric oxide synthesis) level in the nucleus accumbens. Administration of the selective D1 receptor antagonist SCH-23390 (100 microM) into the nucleus accumbens had no long-lasting effect on the extracellular citrulline level in this structure, but reduced the magnitude of the increase in the citrulline level seen on performance of the conditioned reflex fear reaction. These data suggest that the dopaminergic input of the nucleus accumbens acts via D1 receptors to increase NO synthase activity and nitric oxide production during performance of the conditioned reflex fear reaction.
使用高效液相色谱法对斯普拉格-道利大鼠进行的脑内微透析研究表明，条件反射性恐惧反应的表现伴随着伏隔核细胞外瓜氨酸（一氧化氮合成的副产物）水平的升高。向伏隔核注射选择性D1受体拮抗剂SCH-23390（100微摩尔）对该结构中的细胞外瓜氨酸水平没有长期影响，但降低了条件反射性恐惧反应表现时瓜氨酸水平升高的幅度。这些数据表明，伏隔核的多巴胺能输入通过D1受体起作用，在条件反射性恐惧反应的表现过程中增加一氧化氮合酶活性和一氧化氮生成。
