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非小细胞肺癌患者化疗期间血清血管生成素-1、血管生成素-2及其受体Tie-2水平

Serum levels of angiopoietin-1, angiopoietin-2, and their receptor tie-2 in patients with nonsmall cell lung cancer during chemotherapy.

作者信息

Naumnik Wojciech, Chyczewska Elzbieta, Ossolinska Maria

机构信息

Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Poland.

出版信息

Cancer Invest. 2009 Aug;27(7):741-6. doi: 10.1080/07357900802672704.

DOI:10.1080/07357900802672704
PMID:19340656
Abstract

This pilot study was conducted to investigate the prognostic role and the effects of chemotherapy on serum angiogenic factors enzyme-linked immunosorbent assay consisting of Angiopoietin-1 and 2 (Ang-1, Ang-2) and their receptor Tie-2 in patients with advanced stage nonsmall cell lung cancer (NSCLC). Concentration of Ang-2 was higher in NSCLC (n= 40) than in healthy people (n= 15), whereas Ang-1 and Tie-2 were comparable. In our opinion determination of Ang-1, Ang-2, and Tie-2 concentrations have no clinical significance in the prognosis of the survival time in lung cancer and can not be used as a predictor of response to the chemotherapy.

摘要

本前瞻性研究旨在探讨晚期非小细胞肺癌（NSCLC）患者血清血管生成因子酶联免疫吸附测定中血管生成素-1和2（Ang-1、Ang-2）及其受体Tie-2的预后作用和化疗效果。NSCLC患者（n = 40）的Ang-2浓度高于健康人（n = 15），而Ang-1和Tie-2浓度相当。我们认为，测定Ang-1、Ang-2和Tie-2浓度对肺癌生存时间的预后无临床意义，不能作为化疗反应的预测指标。

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