淋巴结比率对口腔鳞状细胞癌生存率的影响。

Impact of nodal ratio on survival in squamous cell carcinoma of the oral cavity.

作者信息

Shrime Mark G, Ma Clement, Gullane Patrick J, Gilbert Ralph W, Irish Jonathan C, Brown Dale H, Goldstein David P

机构信息

Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario.

出版信息

Head Neck. 2009 Sep;31(9):1129-36. doi: 10.1002/hed.21073.

DOI:10.1002/hed.21073

PMID:19340867

Abstract

BACKGROUND

The association between nodal ratio and survival has not been assessed in squamous cell carcinomas of the head and neck.

METHODS

This is a population-based analysis, using the Surveillance, Epidemiology, and End-Results database, to determine whether nodal ratio impacts survival in patients with oral cavity squamous cell carcinoma.

RESULTS

Between 1988 and 2005, 2955 new diagnoses of N(1) or N(2) squamous cell carcinoma of the oral cavity were identified. The mean nodal ratio was 16.9%. Nodal ratio was found to be strongly statistically associated with overall survival in both univariate and multivariate analyses. Patients could be stratified into low- (0% to 6%), moderate- (6% to 12.5%), and high-risk (>12.5%) groups based on nodal ratio.

CONCLUSIONS

In patients with squamous cell carcinoma of the oral cavity, an increased nodal ratio is a strong predictor of decreased survival. Risk of death can be stratified based on nodal ratio.

摘要

背景

头颈部鳞状细胞癌中，淋巴结转移率与生存率之间的关联尚未得到评估。

方法

这是一项基于人群的分析，使用监测、流行病学和最终结果数据库，以确定淋巴结转移率是否影响口腔鳞状细胞癌患者的生存率。

结果

在1988年至2005年期间，共确定了2955例新诊断的口腔N(1)或N(2)鳞状细胞癌病例。平均淋巴结转移率为16.9%。在单变量和多变量分析中，淋巴结转移率均与总生存率存在强烈的统计学关联。根据淋巴结转移率，患者可分为低风险（0%至6%）、中度风险（6%至12.5%）和高风险（>12.5%）组。