淋巴结比率是口腔鳞状细胞癌的独立预后因素。

Lymph node ratio as an independent prognostic factor in oral squamous cell carcinoma.

机构信息

Sydney Head and Neck Cancer Institute and The Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia.

出版信息

Head Neck. 2011 Sep;33(9):1245-51. doi: 10.1002/hed.21600. Epub 2010 Oct 21.

DOI:10.1002/hed.21600

PMID:20967874

Abstract

BACKGROUND

We aimed to validate the lymph node ratio (LNR) as an independent prognostic factor in oral squamous cell carcinoma (OSCC) and compare its utility with the current nodal staging system.

METHODS

We conducted a retrospective analysis of 313 patients with OSCC undergoing neck dissection. The LNR was adjusted by relevant covariates in a multivariable Cox regression model.

RESULTS

LNR displaced conventional nodal staging and was shown to be an independent predictor of regional failure (p = .020), disease-specific (p = .003) and overall survival (p = .001). Patients with an LNR of 2.5% to 7.5%, 7.5% to 20%, and >20% had 2.6, 3.7, and 4.4 times the risk of death from OSCC, respectively, when compared with patients with an LNR <2.5%.

CONCLUSIONS

The LNR is an independent prognostic factor in OSCC and may be used in conjunction with the current TNM staging to enable better risk stratification and selection for adjuvant therapy.

摘要

背景

我们旨在验证淋巴结比率（LNR）作为口腔鳞状细胞癌（OSCC）的独立预后因素，并将其与当前的淋巴结分期系统进行比较。

方法

我们对 313 例接受颈部清扫术的 OSCC 患者进行了回顾性分析。LNR 通过多变量 Cox 回归模型中的相关协变量进行调整。

结果

LNR 取代了传统的淋巴结分期，并且是区域失败（p=0.020）、疾病特异性（p=0.003）和总体生存（p=0.001）的独立预测因素。与 LNR<2.5%的患者相比，LNR 为 2.5%至 7.5%、7.5%至 20%和>20%的患者死于 OSCC 的风险分别增加了 2.6、3.7 和 4.4 倍。