Karolinska Pharmacy, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
J Pharm Sci. 2009 Nov;98(11):3879-85. doi: 10.1002/jps.21732.
Oxaliplatin is used primarily in the treatment of metastatic colorectal cancer. In this minireview, we discuss potentially important biotransformation pathways in light of its short elimination half-life in vivo. We also highlight new information achieved using a selective analytical technique to measure intact oxaliplatin in pharmacokinetic studies (comprising intravenous, intraperitoneal, and intrahepatic administration) and compare to results obtained by measurements of total platinum. The use of selective analytical techniques is strongly recommended giving kinetic parameters of the parent compound and not only to a complex mixture of platinum containing endogenous compounds.
奥沙利铂主要用于转移性结直肠癌的治疗。在这篇简评中，我们根据其在体内较短的消除半衰期，讨论了一些潜在重要的生物转化途径。我们还使用选择性分析技术来测量药代动力学研究中（包括静脉、腹腔和肝内给药）完整奥沙利铂的新信息，并且与总铂测量结果进行比较。强烈建议使用选择性分析技术，因为这样可以获得母体化合物的动力学参数，而不仅仅是包含内源性化合物的复杂铂混合物的参数。
