丙型肝炎病毒与2型糖尿病
Hepatitis C virus and type 2 diabetes.
作者信息
Negro Francesco, Alaei Mahnaz
机构信息
Division of Gastroenterology, Hepatology and Clinical Pathology, University Hospitals, Geneva 14, Switzerland.
出版信息
World J Gastroenterol. 2009 Apr 7;15(13):1537-47. doi: 10.3748/wjg.15.1537.
Abstract
This review focuses on the relationship between hepatitis C virus (HCV) infection and glucose metabolism derangements. Cross-sectional and longitudinal studies have shown that the chronic HCV infection is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). The direct effect of HCV on the insulin signaling has been analyzed in experimental models. Although currently available data should be considered as preliminary, HCV seems to affect glucose metabolism via mechanisms that involve cellular pathways that have been implicated in the host innate immune response. IR and T2D not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the early and sustained virological response to interferon-alpha-based therapy. Thus, a detailed knowledge of the mechanisms underlying the HCV-associated glucose metabolism derangements is warranted, in order to improve the clinical management of chronic hepatitis C patients.
摘要
本综述聚焦于丙型肝炎病毒（HCV）感染与糖代谢紊乱之间的关系。横断面研究和纵向研究表明，慢性HCV感染与发生胰岛素抵抗（IR）和2型糖尿病（T2D）的风险增加相关。已在实验模型中分析了HCV对胰岛素信号传导的直接影响。尽管目前可得的数据应被视为初步的，但HCV似乎通过涉及宿主固有免疫反应相关细胞途径的机制影响糖代谢。IR和T2D不仅加速慢性丙型肝炎的组织学和临床进展，还降低基于干扰素-α治疗的早期和持续病毒学应答。因此，有必要详细了解HCV相关糖代谢紊乱的潜在机制，以改善慢性丙型肝炎患者的临床管理。
相似文献
1
Hepatitis C virus and type 2 diabetes.丙型肝炎病毒与2型糖尿病
World J Gastroenterol. 2009 Apr 7;15(13):1537-47. doi: 10.3748/wjg.15.1537.
2
Current understanding of insulin resistance in hepatitis C.目前对丙型肝炎中胰岛素抵抗的认识。
Expert Rev Gastroenterol Hepatol. 2011 Aug;5(4):503-16. doi: 10.1586/egh.11.43.
3
Hepatitis C virus infection: molecular pathways to insulin resistance.丙型肝炎病毒感染：胰岛素抵抗的分子途径。
Virol J. 2011 Oct 18;8:474. doi: 10.1186/1743-422X-8-474.
4
Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis.慢性病毒性肝炎患者胰岛素抵抗和脂肪变性的病理生理学。
World J Gastroenterol. 2011 Sep 28;17(36):4055-62. doi: 10.3748/wjg.v17.i36.4055.
5
Hepatitis C virus-associated insulin resistance: pathogenic mechanisms and clinical implications.丙型肝炎病毒相关的胰岛素抵抗：发病机制及临床意义。
Expert Rev Anti Infect Ther. 2011 May;9(5):525-33. doi: 10.1586/eri.11.33.
6
Glucose abnormalities in hepatitis C virus infection.丙型肝炎病毒感染中的葡萄糖异常。
Kaohsiung J Med Sci. 2013 Feb;29(2):61-8. doi: 10.1016/j.kjms.2012.11.001. Epub 2012 Dec 29.
7
Incidence of type 2 diabetes mellitus and glucose abnormalities in patients with chronic hepatitis C infection by response to treatment: results of a cohort study.根据治疗反应分析慢性丙型肝炎感染患者2型糖尿病和血糖异常的发病率：一项队列研究的结果
Am J Gastroenterol. 2008 Oct;103(10):2481-7. doi: 10.1111/j.1572-0241.2008.02002.x. Epub 2008 Aug 8.
8
Mechanism of Hepatitis C Virus-Induced Diabetes Mellitus.丙型肝炎病毒诱发糖尿病的机制
Crit Rev Eukaryot Gene Expr. 2017;27(4):363-371. doi: 10.1615/CritRevEukaryotGeneExpr.2017020437.
9
[Type 2 diabetes mellitus, insulin resistance and hepatocellular carcinoma in chronic hepatitis C patients. ].[丙型慢性肝炎患者中的2型糖尿病、胰岛素抵抗与肝细胞癌。]
Orv Hetil. 2019 Oct;160(40):1591-1602. doi: 10.1556/650.2019.31522.
10
Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients.慢性丙型肝炎患者中糖尿病和胰岛素抵抗的患病率：与乙型肝炎病毒感染和丙型肝炎病毒清除患者的比较。
Liver Int. 2008 Mar;28(3):355-62. doi: 10.1111/j.1478-3231.2007.01630.x.
引用本文的文献
1
Impact of Direct-Acting Antivirals on Extrahepatic Manifestations in Chronic Hepatitis C: A Narrative Review with a Hermeneutic Approach.直接作用抗病毒药物对慢性丙型肝炎肝外表现的影响：一项采用诠释学方法的叙述性综述
Healthcare (Basel). 2025 Aug 9;13(16):1953. doi: 10.3390/healthcare13161953.
2
Burden of intestinal parasites among diabetic patients in Africa: a systematic review and meta-analysis.非洲糖尿病患者肠道寄生虫负担：系统评价与荟萃分析
BMC Infect Dis. 2025 Jan 11;25(1):54. doi: 10.1186/s12879-025-10441-4.
3
Non-human primate model of long-COVID identifies immune associates of hyperglycemia.长新冠非人类灵长类动物模型鉴定出与高血糖相关的免疫标志物。
Nat Commun. 2024 Aug 20;15(1):6664. doi: 10.1038/s41467-024-50339-4.
4
S100A8/A9-activated IFNγ NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis.S100A8/A9 激活的 IFNγ NK 细胞在乙型肝炎病毒相关性肝硬化中引发β细胞坏死性凋亡。
Cell Mol Life Sci. 2024 Aug 12;81(1):345. doi: 10.1007/s00018-024-05365-2.
5
Metabolic disorders and hepatitis: Insights from a Mendelian randomization study.代谢紊乱与肝炎：孟德尔随机化研究的见解
World J Gastrointest Surg. 2024 Jun 27;16(6):1775-1790. doi: 10.4240/wjgs.v16.i6.1775.
6
Independent Associations of Aortic Calcification with Cirrhosis and Liver Related Mortality in Veterans with Chronic Liver Disease.慢性肝病退伍军人中主动脉钙化与肝硬化及肝脏相关死亡率的独立相关性。
Dig Dis Sci. 2024 Jul;69(7):2681-2690. doi: 10.1007/s10620-024-08450-5. Epub 2024 Apr 23.
7
HCV affects K channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic β-cells leading to impaired insulin secretion.丙型肝炎病毒通过 GnT-IVa 介导的胰腺β细胞表面 GLUT2 的 N-糖基化作用影响 K 通道，导致胰岛素分泌受损。
Endocrine. 2024 May;84(2):427-440. doi: 10.1007/s12020-023-03589-z. Epub 2023 Nov 14.
8
Neutrophil (dys)function due to altered immuno-metabolic axis in type 2 diabetes: implications in combating infections.中性粒细胞（功能）障碍与 2 型糖尿病中免疫代谢轴的改变有关：在抗感染中的意义。
Hum Cell. 2023 Jul;36(4):1265-1282. doi: 10.1007/s13577-023-00905-7. Epub 2023 Apr 28.
9
Intestinal parasites and diabetes: A systematic review and meta-analysis.肠道寄生虫与糖尿病：一项系统综述和荟萃分析
New Microbes New Infect. 2022 Dec 24;51:101065. doi: 10.1016/j.nmni.2022.101065. eCollection 2023 Jan.
10
HCV infection characteristics, treatment uptake and outcomes in patient with diabetes mellitus.丙型肝炎病毒感染特征、糖尿病患者的治疗接受情况和结局。
BMC Endocr Disord. 2022 Nov 12;22(1):277. doi: 10.1186/s12902-022-01198-x.
本文引用的文献
1
Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin.在初治的基因型1慢性丙型肝炎患者中，使用二甲双胍治疗胰岛素抵抗，这些患者同时接受聚乙二醇干扰素α-2a加利巴韦林治疗。
Hepatology. 2009 Dec;50(6):1702-8. doi: 10.1002/hep.23206.
2
Hepatitis C virus infection and post-transplant diabetes mellitus among renal transplant patients: a meta-analysis.肾移植患者中的丙型肝炎病毒感染与移植后糖尿病：一项荟萃分析。
Int J Artif Organs. 2008 Aug;31(8):675-82. doi: 10.1177/039139880803100801.
3
Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis.丙型肝炎感染与糖尿病风险：一项系统评价和荟萃分析。
J Hepatol. 2008 Nov;49(5):831-44. doi: 10.1016/j.jhep.2008.08.006. Epub 2008 Aug 21.
4
Risk factors for the development of diabetes mellitus in chronic hepatitis C virus genotype 4 infection.慢性丙型肝炎病毒4型感染中糖尿病发生的危险因素。
J Gastroenterol Hepatol. 2009 Jan;24(1):42-8. doi: 10.1111/j.1440-1746.2008.05503.x. Epub 2008 Aug 20.
5
Incidence of type 2 diabetes mellitus and glucose abnormalities in patients with chronic hepatitis C infection by response to treatment: results of a cohort study.根据治疗反应分析慢性丙型肝炎感染患者2型糖尿病和血糖异常的发病率：一项队列研究的结果
Am J Gastroenterol. 2008 Oct;103(10):2481-7. doi: 10.1111/j.1572-0241.2008.02002.x. Epub 2008 Aug 8.
6
Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C.慢性丙型肝炎中胰岛素抵抗、脂肪变性和纤维化的基因型特异性相互作用
Hepatology. 2008 Sep;48(3):723-31. doi: 10.1002/hep.22392.
7
Insulin resistance is a major determinant of sustained virological response in genotype 1 chronic hepatitis C patients receiving peginterferon alpha-2b plus ribavirin.胰岛素抵抗是基因型 1 慢性丙型肝炎患者接受聚乙二醇干扰素α-2b 联合利巴韦林治疗后持续病毒学应答的主要决定因素。
Aliment Pharmacol Ther. 2009 Jan;29(1):46-54. doi: 10.1111/j.1365-2036.2008.03823.x. Epub 2008 Aug 1.
8
Evaluation of risk factors and seroprevalence of hepatitis B and C in diabetic patients in Kutahya, Turkey.土耳其屈塔希亚糖尿病患者的乙肝和丙肝危险因素及血清学流行率评估
J Investig Med. 2008 Aug;56(6):858-63. doi: 10.2310/JIM.0b013e3181788d28.
9
Reappraisal of the characteristics of glucose abnormalities in patients with chronic hepatitis C infection.慢性丙型肝炎感染患者血糖异常特征的重新评估。
Am J Gastroenterol. 2008 Aug;103(8):1933-40. doi: 10.1111/j.1572-0241.2008.01996.x. Epub 2008 Jul 12.
10
Serum adipokine levels in chronic liver diseases: association of resistin levels with fibrosis severity.慢性肝病患者血清脂肪因子水平：抵抗素水平与肝纤维化严重程度的关联
Scand J Gastroenterol. 2008;43(9):1128-36. doi: 10.1080/00365520802085387.
Zotero 插件