斑节对虾（凡纳滨对虾）的一种细胞基因产物——活化蛋白激酶C1受体（Pm-RACK1）的鉴定，该受体与白斑综合征病毒的一种蛋白VP9相互作用。
Identification of a receptor for activated protein kinase C1 (Pm-RACK1), a cellular gene product from black tiger shrimp (Penaeus monodon) interacts with a protein, VP9 from the white spot syndrome virus.
作者信息
Tonganunt Moltira, Saelee Netnapa, Chotigeat Wilaiwan, Phongdara Amornrat
机构信息
Center for Genomics and Bioinformatics Research, Faculty of Science, Prince of Songkla University, 15 Karnjanavanit Road, Songkhla 90110, Thailand.
出版信息
Fish Shellfish Immunol. 2009 Mar;26(3):509-14. doi: 10.1016/j.fsi.2009.02.002.
A gene encoding a receptor for activated protein kinase C1 homolog has been isolated from the shrimp, Penaeus monodon (Pm-RACK1). The full length Pm-RACK1 cDNA has 957 bp, and an open reading frame encoding a protein of 318 amino acid residues. The protein contains seven WD40 repeats and shares approximately 78% identity with vertebrate RACK1. In adult shrimp, Pm-RACK1 transcripts were detected in all tissues. During WSSV infection, Pm-RACK1 was upregulated in hepatopancreas, stomach and hemocytes. We identified Pm-RACK1 as a specific cellular target protein for VP9, a nonstructural protein of WSSV. The interaction of these two proteins may be involved in mediating intracellular VP9 functions.
已从斑节对虾（Penaeus monodon）中分离出一种编码活化蛋白激酶C1同源物受体的基因（Pm-RACK1）。Pm-RACK1 cDNA全长957 bp，有一个编码318个氨基酸残基蛋白质的开放阅读框。该蛋白质包含七个WD40重复序列，与脊椎动物RACK1的同源性约为78%。在成年对虾中，所有组织均检测到Pm-RACK1转录本。在白斑综合征病毒（WSSV）感染期间，肝胰腺、胃和血细胞中的Pm-RACK1上调。我们确定Pm-RACK1是WSSV非结构蛋白VP9的特异性细胞靶蛋白。这两种蛋白质的相互作用可能参与介导细胞内VP9的功能。
Zotero 插件