• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Release of N2,3-ethanoguanine from haloethylnitrosourea-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.

作者信息

Habraken Y, Carter C A, Sekiguchi M, Ludlum D B

机构信息

Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.

出版信息

Carcinogenesis. 1991 Oct;12(10):1971-3. doi: 10.1093/carcin/12.10.1971.

DOI:10.1093/carcin/12.10.1971
PMID:1934281
Abstract

3-Methyladenine DNA glycosylase II (Gly II), purified from Escherichia coli cells which carry the plasmid PYN1000, has been tested for its ability to release N2,3-ethanoguanine from DNA modified by the antitumor agent N-[2-chloroethyl-1,2-14C]-N'-cyclohexyl-N-nitrosourea ([14C]CCNU). Gly II has been shown to release N2,3-ethanoguanine in a protein- and time-dependent manner at a rate that exceeds the rate at which this enzyme releases other alkylated bases from [14C]CCNU-modified DNA. This finding widens the known substrate specificity for Gly II to include a modified base which bears an exocyclic ring structure, a class of modifications caused by a variety of chemical carcinogens.

摘要

相似文献

1
Release of N2,3-ethanoguanine from haloethylnitrosourea-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.
Carcinogenesis. 1991 Oct;12(10):1971-3. doi: 10.1093/carcin/12.10.1971.
2
Release of 7-alkylguanines from haloethylnitrosourea-treated DNA by E. coli 3-methyladenine-DNA glycosylase II.
Biochem Biophys Res Commun. 1988 Sep 30;155(3):1261-5. doi: 10.1016/s0006-291x(88)81276-2.
3
Release of 7-alkylguanines from N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea-modified DNA by 3-methyladenine DNA glycosylase II.3-甲基腺嘌呤DNA糖基化酶II从N-(2-氯乙基)-N'-环己基-N-亚硝基脲修饰的DNA中释放7-烷基鸟嘌呤。
Cancer Res. 1991 Jan 15;51(2):499-503.
4
Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.大肠杆菌3-甲基腺嘌呤DNA糖基化酶II从氯乙醛处理的DNA中释放N2,3-乙烯基鸟嘌呤
Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9331-4. doi: 10.1073/pnas.89.19.9331.
5
Release of sulfur mustard-modified DNA bases by Escherichia coli 3-methyladenine DNA glycosylase II.
Carcinogenesis. 1996 Oct;17(10):2249-52. doi: 10.1093/carcin/17.10.2249.
6
Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine.大肠杆菌中的两种DNA糖基化酶，主要释放3-甲基腺嘌呤。
Biochemistry. 1982 Mar 16;21(6):1162-9. doi: 10.1021/bi00535a009.
7
Formation of N2,3-ethanoguanine in DNA after in vitro treatment with the therapeutic agent, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea.用治疗剂N-(2-氯乙基)-N'-环己基-N-亚硝基脲进行体外处理后，DNA中N2,3-乙撑鸟嘌呤的形成。
Carcinogenesis. 1990 Feb;11(2):223-8. doi: 10.1093/carcin/11.2.223.
8
Excision of 3-methylguanine from alkylated DNA by 3-methyladenine DNA glycosylase I of Escherichia coli.大肠杆菌的3-甲基腺嘌呤DNA糖基化酶I从烷基化DNA中切除3-甲基鸟嘌呤。
Nucleic Acids Res. 1993 May 11;21(9):2045-9. doi: 10.1093/nar/21.9.2045.
9
Release of chloroethyl ethyl sulfide-modified DNA bases by bacterial 3-methyladenine-DNA glycosylases I and II.
Carcinogenesis. 1989 Mar;10(3):489-92. doi: 10.1093/carcin/10.3.489.
10
Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.真核生物3-甲基腺嘌呤DNA糖基化酶对氯乙基亚硝基脲细胞毒性的保护作用。
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11855-9. doi: 10.1073/pnas.90.24.11855.

引用本文的文献

1
Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase.通过分子动力学模拟对人烷基嘌呤-DNA N-糖基化酶修复乙醇-A 加合物与乙烯-A 加合物的差异效率的结构见解。
Nucleic Acids Res. 2002 Sep 1;30(17):3778-87. doi: 10.1093/nar/gkf494.
2
2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity.2-羟基-dATP被大肠杆菌DNA聚合酶III掺入到与鸟嘌呤相对的位置，导致高致突变性。
Nucleic Acids Res. 2000 Apr 1;28(7):1640-6. doi: 10.1093/nar/28.7.1640.
3
Release of normal bases from intact DNA by a native DNA repair enzyme.
一种天然DNA修复酶从完整DNA中释放正常碱基。
EMBO J. 1998 Jan 15;17(2):363-7. doi: 10.1093/emboj/17.2.363.
4
DNA glycosylases in the base excision repair of DNA.DNA碱基切除修复中的DNA糖基化酶。
Biochem J. 1997 Jul 1;325 ( Pt 1)(Pt 1):1-16. doi: 10.1042/bj3250001.
5
Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.修复缺陷型3-甲基腺嘌呤DNA糖基化酶纯合突变小鼠细胞对烷基化诱导的染色体损伤和细胞杀伤的敏感性增加。
EMBO J. 1996 Feb 15;15(4):945-52.
6
Purification and characterization of human 3-methyladenine-DNA glycosylase.人 3-甲基腺嘌呤-DNA 糖基化酶的纯化与鉴定
Nucleic Acids Res. 1993 Dec 11;21(24):5561-9. doi: 10.1093/nar/21.24.5561.
7
Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.真核生物3-甲基腺嘌呤DNA糖基化酶对氯乙基亚硝基脲细胞毒性的保护作用。
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11855-9. doi: 10.1073/pnas.90.24.11855.
8
Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases.大肠杆菌、酵母、大鼠和人类烷基嘌呤DNA糖基化酶从含有dIMP残基的DNA中切除次黄嘌呤。
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5873-7. doi: 10.1073/pnas.91.13.5873.
9
Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.环外DNA加合物的诱变潜能：大肠杆菌与猴肾细胞之间的显著差异。
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11899-903. doi: 10.1073/pnas.91.25.11899.
10
Escherichia coli, Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N6-ethenoadenine when present in DNA.大肠杆菌、酿酒酵母、大鼠和人类的3-甲基腺嘌呤DNA糖基化酶在DNA中存在1,N6-乙烯腺嘌呤时会对其进行修复。
Nucleic Acids Res. 1995 Sep 25;23(18):3750-5. doi: 10.1093/nar/23.18.3750.