Bosset Jean-François, Bosset Mathieu, Nguyen France, Servagi-Vernat Stéphanie, Sedrati Abdeslem
Department of Radiation Oncology, Besançon University Hospital, Besançon, France.
Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S54-7.
Preoperative treatments for patients with T3 rectal cancer have significantly improved local recurrence rates, while survival outcomes have not changed significantly relative to those achieved with surgery alone. The prognosis of patients with T3 tumors, however, is heterogeneous; therapy should be carefully selected based on characteristics of the tumor and other prognostic indices to provide an optimal outcome for each patient. This paper summarizes key findings from several large trials that have examined use of preoperative radiotherapy and chemoradiotherapy for rectal cancer, how these results can be applied to selection of the best therapy for an individual patient, as well as prognostic/predictive factors that have been identified and clinical tools for measuring them.
T3期直肠癌患者的术前治疗显著提高了局部复发率，而相对于单纯手术治疗，生存结果并无显著变化。然而，T3期肿瘤患者的预后存在异质性；应根据肿瘤特征和其他预后指标仔细选择治疗方法，为每位患者提供最佳治疗效果。本文总结了几项大型试验的主要发现，这些试验研究了直肠癌术前放疗和放化疗的应用、如何将这些结果应用于为个体患者选择最佳治疗方法，以及已确定的预后/预测因素和测量这些因素的临床工具。
