McIsaac Sean A, Young Allan H
Institute of Mental Health, University of British Columbia, Vancouver, British Columbia, Canada.
Drugs Today (Barc). 2009 Feb;45(2):127-33. doi: 10.1358/dot.2009.45.2.1336104.
There is a growing body of evidence regarding the abnormalities of cortisol and its regulatory system in both unipolar and bipolar depression. Cortisol may contribute to some of the symptoms experienced by depressed persons. There is a complex, bidirectional relationship between serotonergic and stress systems and disruption of one may create a cascade of events that will lead to ill health. Novel therapeutic approaches that modulate cortisol are now being evaluated experimentally in order to increase treatment options for depression and improve patient outcome.
关于单相和双相抑郁症中皮质醇及其调节系统异常的证据越来越多。皮质醇可能导致抑郁症患者出现的一些症状。血清素能系统与应激系统之间存在复杂的双向关系，其中一个系统的紊乱可能引发一系列导致健康问题的事件。目前正在通过实验评估调节皮质醇的新型治疗方法，以增加抑郁症的治疗选择并改善患者预后。
