儿童阿托伐他汀治疗糖尿病试验（PADIT）：一项关于确定阿托伐他汀对1型糖尿病儿童动脉僵硬度和内皮功能影响的初步研究。
Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus.
作者信息
Haller Michael J, Stein Jennifer M, Shuster Jonathan J, Theriaque Douglas, Samyn Margaret M, Pepine Carl, Silverstein Janet H
机构信息
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
出版信息
J Pediatr Endocrinol Metab. 2009 Jan;22(1):65-8. doi: 10.1515/jpem.2009.22.1.65.
Abstract
Fifty-one children with type 1 diabetes mellitus (DM1) participated in a double blinded, randomized, cross-over pilot study to determine whether 12 weeks of daily atorvastatin (20 mg daily) would reduce arterial stiffness and improve endothelial function. Secondary analysis demonstrated potential reduction of arterial stiffness following atorvastatin therapy (p = 0.06). Additional long-term prospective studies with larger numbers of patients are needed.
摘要
51名1型糖尿病（DM1）患儿参与了一项双盲、随机、交叉试验性研究，以确定每日服用阿托伐他汀（每日20毫克）12周是否会降低动脉僵硬度并改善内皮功能。二次分析表明，阿托伐他汀治疗后动脉僵硬度有潜在降低（p = 0.06）。需要开展更多针对大量患者的长期前瞻性研究。
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