生成新的血流：整合发育生物学与组织工程学

Generating new blood flow: integrating developmental biology and tissue engineering.

作者信息

Krenning Guido, Moonen Jan-Renier A J, van Luyn Marja J A, Harmsen Martin C

机构信息

Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein, The Netherlands.

出版信息

Trends Cardiovasc Med. 2008 Nov;18(8):312-23. doi: 10.1016/j.tcm.2009.01.004.

DOI:10.1016/j.tcm.2009.01.004

PMID:19345319

Abstract

Vascular tissue engineering aims to restore blood flow by seeding artificial tubular scaffolds with endothelial and smooth muscle cells, thus creating bioartificial blood vessels. Herein, the progenitors of smooth muscle and endothelial cells hold great promise because they efficiently differentiate and harbor longevity. In this review, we describe a novel tissue engineering approach that uses current insights from developmental biology, that is, progenitor cell plasticity, and the latest advances in biomaterial design. We focus specifically on developmental processes that regulate progenitor cell (trans)differentiation and offer a platform for the integration of these molecular clues into biomaterial design. We propose a novel engineering paradigm for the creation of a small-diameter blood vessel wherein progenitor cell differentiation and tissue organization are instructed by the biomaterial solely. With this review, we emphasize the power of integrating developmental biology and material science for vascular tissue engineering.

摘要

血管组织工程旨在通过将内皮细胞和平滑肌细胞接种到人工管状支架上以恢复血流，从而制造生物人工血管。在此，平滑肌细胞和内皮细胞的祖细胞具有巨大潜力，因为它们能高效分化且具有较长寿命。在本综述中，我们描述了一种新颖的组织工程方法，该方法利用发育生物学的当前见解，即祖细胞可塑性，以及生物材料设计的最新进展。我们特别关注调节祖细胞（转）分化的发育过程，并提供一个将这些分子线索整合到生物材料设计中的平台。我们提出了一种用于创建小直径血管的新颖工程范式，其中祖细胞分化和组织构建仅由生物材料引导。通过本综述，我们强调了将发育生物学和材料科学整合用于血管组织工程的作用。