常见可变免疫缺陷中血清CD8、CD25和β2-微球蛋白水平升高。
Raised serum levels of CD8, CD25 and beta 2-microglobulin in common variable immunodeficiency.
作者信息
North M E, Spickett G P, Webster A D, Farrant J
机构信息
Immunodeficiency Diseases Research Group, Clinical Research Centre, Harrow, England, UK.
出版信息
Clin Exp Immunol. 1991 Nov;86(2):252-5. doi: 10.1111/j.1365-2249.1991.tb05805.x.
Soluble CD8, soluble CD4, soluble CD25 (IL-2 receptor), beta 2-microglobulin and the cytokine tumour necrosis factor-alpha (TNF-alpha) were measured in sera from patients with common variable immunodeficiency (CVI). Levels of soluble CD8, soluble CD25 and beta 2-microglobulin but not of soluble CD4 and TNF-alpha were raised significantly above levels in normal sera. Sera from patients with X-linked agammaglobulinaemia, who are also antibody deficient, did not show this marked elevation. The raised levels of soluble CD8, soluble CD25 and beta 2-microglobulin in CVI, correlated with the extent of the defects in the B lymphocytes assessed in vitro, as well as with the clinical severity of the disease. The selective release of these molecules into sera may indicate that abnormal cellular activation occurs in most CVI patients. It is also possible that the raised levels of these soluble molecules play a part in the immunodeficiency.
在常见可变免疫缺陷（CVI）患者的血清中检测了可溶性CD8、可溶性CD4、可溶性CD25（白细胞介素-2受体）、β2-微球蛋白和细胞因子肿瘤坏死因子-α（TNF-α）。可溶性CD8、可溶性CD25和β2-微球蛋白的水平显著高于正常血清中的水平，但可溶性CD4和TNF-α的水平没有升高。同样存在抗体缺陷的X连锁无丙种球蛋白血症患者的血清并未显示出这种明显升高。CVI患者中可溶性CD8、可溶性CD25和β2-微球蛋白水平的升高，与体外评估的B淋巴细胞缺陷程度以及疾病的临床严重程度相关。这些分子选择性释放到血清中可能表明大多数CVI患者发生了异常细胞活化。这些可溶性分子水平的升高也可能在免疫缺陷中起作用。
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